Inferred from mouse:Interleukin-23 receptor subunit (Il23r) can be phosphoryated at various intracellular Tyrosin residues. Tyr-542 and Tyr-626 aminoacid residues in murine Il23r are responsible for SH2 domain dependent Signal transducer and activator of transcription 3 (Stat3) activation (Floss et al. 2013). Moreover Western blot data demostrated Interleukin-23 dependent trysoine phosphorylation of Stat3 in cotransfected parental cell lines(2C4, 2fTGH) and Tyrosine-protein kinase JAK1(Jak1)-deficient cells (U4C) (Floss et al.2016).As the process of phosphorylation is not clear this reaction is represented here as a black box event.
transmembrane receptor protein tyrosine kinase activity of IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane]
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