Vesicle-associated membrane protein 7 (VAMP7) plays a dual role in Interleukin-12 heterodimeric protein secretion. In individual Dendritic cells, its basic function is as a positive regulator, regulating the optimal exocytosis of biologically active Interleukin-12 heterodimer produced by inflammatory stimuli. The second essential role of VAMP7 is as a negative regulator, controling non-redundantly synaptic secretion of the cytokine during interaction with a cognate T cell, i.e., at the immune synapse. Multivesicular bodies are regulated by VAMP7 and consequently Interleukin-12 heterodimer secretion is regulated by this VAMP7 (Chiaruttini et al. 2016).
De Nardi, F,