IL12A:IL12B translocates from late endosome lumen to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
Interleukin-12 translocates to the extracellular space, IL12A:IL12B complex is translocated to the extracellular space, Interleukin-12A:Interleukin12-B complex is translocated to the extracellular space
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Vesicle-associated membrane protein 7 (VAMP7) plays a dual role in Interleukin-12 heterodimeric protein secretion. In individual Dendritic cells, its basic function is as a positive regulator, regulating the optimal exocytosis of biologically active Interleukin-12 heterodimer produced by inflammatory stimuli. The second essential role of VAMP7 is as a negative regulator, controling non-redundantly synaptic secretion of the cytokine during interaction with a cognate T cell, i.e., at the immune synapse. Multivesicular bodies are regulated by VAMP7 and consequently Interleukin-12 heterodimer secretion is regulated by this VAMP7 (Chiaruttini et al. 2016).

Literature References
PubMed ID Title Journal Year
26972013 The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells

De Nardi, F, Galli, T, Benvenuti, F, Larghi, P, Müller, S, Piperno, GM, Jouve, M, Chiaruttini, G, Valitutti, S, Peden, AA, Baj, G

Cell Rep 2016
This event is regulated
Cite Us!