2xIL12B

Stable Identifier
R-HSA-8950291
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
IL12B dimer
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Summation

Interleukin-12 subunit beta can homodimerize with other equal subunit. This homodimer can be stabilized by mean of protein disulfide isomerase which create a disulfide binding between both subunits in the endoplasmic reticulum(PMID:11054122).

Literature References
PubMed ID Title Journal Year
11054122 Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers

Martens, E, Alloza, I, Scott, CJ, Billiau, A, Vandenbroeck, K

Eur. J. Biochem. 2000
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