2xIL12B [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-8950291
Type
Complex
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
IL12B dimer
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General
Interleukin-12 subunit beta can homodimerize with other equal subunit. This homodimer can be stabilized by mean of protein disulfide isomerase which create a disulfide binding between both subunits in the endoplasmic reticulum(PMID:11054122).
Literature References
PubMed ID Title Journal Year
11054122 Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers

Vandenbroeck, K, Billiau, A, Alloza, I, Scott, CJ, Martens, E

Eur. J. Biochem. 2000
Participants
components
Participates
as an output of
as an input of
Inferred To
2xIL12B [endoplasmic reticulum lumen] (Bos taurus)
2xIL12B [endoplasmic reticulum lumen] (Canis familiaris)
2xIL12B [endoplasmic reticulum lumen] (Danio rerio)
2xIL12B [endoplasmic reticulum lumen] (Gallus gallus)
2xIL12B [endoplasmic reticulum lumen] (Mus musculus)
2xIL12B [endoplasmic reticulum lumen] (Rattus norvegicus)
2xIL12B [endoplasmic reticulum lumen] (Sus scrofa)
2xIL12B [endoplasmic reticulum lumen] (Xenopus tropicalis)
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