IL12B:IL23A [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-8950275
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
IL23p19:IL12p40
Locations in the PathwayBrowser
General

Interleukin-23 heterodimer is formed by Interleukin-23 subunit alpha (IL23p19 or p19 or IL23A) and Interleukin-12 subunit beta (IL12B or p40 or IL12p40). Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding netwrok with residues at the base of a pocket on p40. (PMID: 18680750) This dimer can be retained in the Endoplasmic reticulum upon TFM-C (4-trifluoromethyl-celecobix) treatment (PMID:20054003)

Literature References
PubMed ID Title Journal Year
20054003 Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP

McLaughlin, M, Alloza, I, Quoc, HP, Scott, CJ, Hirabayashi, Y, Vandenbroeck, K

J. Biol. Chem. 2010
18680750 The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12

Lupardus, PJ, Garcia, KC

J. Mol. Biol. 2008
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