IL12A:IL12B

Stable Identifier
R-HSA-8950228
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Inferred from mouse :
Interleukin-12, (IL12) formed from Interleukin-12 subunit alpha (IL12A) and Interleukin-12 subunit beta (IL12B), has been localized intracellularly in late endocytic vesicles expresing the marker protein termed Vesicle-associated membrane protein 7 (VAMP7) (Chiaruttini et al. 2016).

This reaction is a black box event because we do not fully understand the mechanism of translocation.

Literature References
PubMed ID Title Journal Year
26972013 The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells

Chiaruttini, G, Piperno, GM, Jouve, M, De Nardi, F, Larghi, P, Peden, AA, Baj, G, Müller, S, Valitutti, S, Galli, T, Benvenuti, F

Cell Rep 2016
Participants
Participant Of