IL12A:IL12B [Golgi lumen]

Stable Identifier
R-HSA-8950228
Type
Complex
Species
Homo sapiens
Compartment
Golgi lumen
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General

Inferred from mouse :
Interleukin-12, (IL12) formed from Interleukin-12 subunit alpha (IL12A) and Interleukin-12 subunit beta (IL12B), has been localized intracellularly in late endocytic vesicles expresing the marker protein termed Vesicle-associated membrane protein 7 (VAMP7) (Chiaruttini et al. 2016).

This reaction is a black box event because we do not fully understand the mechanism of translocation.

Literature References
PubMed ID Title Journal Year
26972013 The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells

De Nardi, F, Galli, T, Benvenuti, F, Larghi, P, Müller, S, Piperno, GM, Jouve, M, Chiaruttini, G, Valitutti, S, Peden, AA, Baj, G

Cell Rep 2016
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