IL12B binds IL23A

Stable Identifier
R-HSA-8950183
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-12 subunit beta binds Interleukin-23 subunit alpha forming Interleukin-23, Interleukin-12B binds Interleukin-23A forming Interleukin-23, Interleukin-12B binds Interleukin-23A
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Interleukin 23 subunit alpha (IL23A, IL23-p19) and Interleukin 12 subunit beta (IL12B, IL-12p40) bind to form the Interleukin-23 (IL23) heterodimeric complex (IL23A:IL12B). When 293T cells were transfected with IL23A only a small amount of protein could be immunoprecipitated from the supernatant, while protein was readily detected in cellular lysates, indicating inefficient secretion. Co expression of IL23A with IL12B enhanced secretion of IL23 (Oppmann et al. 2000). Moreover there is a disulfide bridge within IL12A which is necessary fro IL12B-induced secretion. Protein disulfide isomerases enable the formation of these bridges (Reitberger et al. 2017).

Literature References
PubMed ID Title Journal Year
11114383 Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

Oppmann, B, Lesley, R, Blom, B, Timans, JC, Xu, Y, Hunte, B, Vega, F, Yu, N, Wang, J, Singh, K, Zonin, F, Vaisberg, E, Churakova, T, Liu, M, Gorman, D, Wagner, J, Zurawski, S, Liu, Y, Abrams, JS, Moore, KW, Rennick, D, de Waal-Malefyt, R, Hannum, C, Bazan, JF, Kastelein, RA

Immunity 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein disulfide isomerase activity of P4HB [endoplasmic reticulum lumen]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created