Interleukin-12 dissociates from Interleukin-12 receptor

Stable Identifier
R-HSA-8950128
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Interleukin-12 dissociates from Interleukin-12 receptor
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Based on competition experiments with Iodine125-labeled Interleukin-12 (IL12) it was determined that IL12 can dissociate from the Interleukin-12 receptor. The association kinetics suggest mostly subsequent internalization of the IL12 (Chizzonite et al. 1992).
Literature References
PubMed ID Title Journal Year
9498755 Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex

Minetti, LJ, Presky, DH, Wilkinson, VL, Chizzonite, R, Gubler, U, Gately, MK, Gillessen, S, Wu, CY

J. Immunol. 1998
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Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
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