The intracellular domain of human Interleukin-12 receptor subunit beta-1 (IL12RB1) but not the intracellular domain of Interleukin-12 receptor subunit beta-2 (IL12RB2) interacts directly with Non-receptor tyrosine-protein kinase (TYK2) (Zou et al. 1997)
Inferred from mouse:
TYK2 associates with IL12RB1. In the absence of TYK2, IL12RB1 can associate with Tyrosine-protein kinase JAK1 (JAK1) (Floss et al. 2016).