IL12RB1:TYK2:IL12RB2:JAK2

Stable Identifier
R-HSA-8950052
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Experimental evidence shows that human IL-12Rbeta2, similar to human IL12Rbeta1, appears to exist at the cell surface as a disulfide bonded dimer/oligomer. Formation of this human Interleukin-12Rbeta2 oligomer is not dependent on Interleukin-12 binding, since it was observed in cells that were never exposed to Interleukin-12 heterodimeric protein.
Interleukin-12 receptor beta1 does not contain any cytoplasmic tyrosine residues, whereas the cytoplasmic region of Interleulin-12 receptor beta2 contains three tyrosine residues. This last has an important role for the beta 2 subunit in Interleukin-12 signal transduction (PMID: 8943050). Based on (Kotenko et. al., 1996, PMID: 8663414) signal transduction receptor chains can be divided into two classes. IL12RB2 would be of the first class : signal transducers (ST) with STAT (or SH2 domain-containg proteins) recruitment sites (SRS) and Jak association sites (JAS) . Whereas IL12RB1 would be the the second class: helper receptors (HR) containg only JAS and no SRS (PMID:27193299 )

Literature References
PubMed ID Title Journal Year
8663414 Other kinases can substitute for Jak2 in signal transduction by interferon-gamma

Kotenko, SV, Izotova, LS, Pollack, BP, Muthukumaran, G, Paukku, K, Silvennoinen, O, Ihle, JN, Pestka, S

J. Biol. Chem. 1996
8943050 A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

Presky, DH, Yang, H, Minetti, LJ, Chua, AO, Nabavi, N, Wu, CY, Gately, MK, Gubler, U

Proc Natl Acad Sci U S A 1996
7911493 Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130

Chua, AO, Chizzonite, R, Desai, BB, Truitt, TP, Nunes, P, Minetti, LJ, Warrier, RR, Presky, DH, Levine, JF, Gately, MK

J. Immunol. 1994
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