IL12RB2:JAK2 [plasma membrane]

Stable Identifier
R-HSA-8950039
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General

Inferred from mouse and muse-human protein interaction: There is experimental evidence that show that murine protein Tyrosin kinase Jak2(Jak2) (PMID: 9001223) associates with IL-12Rbeta2 (Interleukin-12 recetor subunit beta 2) directly and IL-12Rbeta1(Interleukin-12 recetor subunit beta 1) and Tyk2(Non-receptor tyrosine-protein kinase TYK2) are not required for the association between IL-12Rbeta2 and Jak2. (PMID:27193299)Stimulation with rhIL-12(recombinant human Interleukin-12) didn’t alter the association between IL-12Rbeta2 and Jak2 in COS 7 cells expressing IL-12Rbeta2, IL-12Rbeta1, Jak2 and Tyk2 (PMID:10198225) In conclusion the amino-terminus of Jak2 is necessary for association with IL-12Rbeta2. Thus Jak2 binds to the cytoplasmatic membrane-proximal region of IL-12Rbeta2, and box2 motif and tyrosine residues in the cytoplasmic domain are not required for binding (PMID:10198225)

Literature References
PubMed ID Title Journal Year
9001223 A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses

Kohlhuber, F, Rogers, NC, Watling, D, Feng, J, Guschin, D, Briscoe, J, Witthuhn, BA, Kotenko, SV, Pestka, S, Stark, GR, Ihle, JN, Kerr, IM

Mol. Cell. Biol. 1997
27193299 Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases

Floss, DM, Klöcker, T, Schröder, J, Lamertz, L, Mrotzek, S, Strobl, B, Hermanns, H, Scheller, J

Mol. Biol. Cell 2016
10198225 Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus

Yamamoto, K, Shibata, F, Miura, O, Kamiyama, R, Hirosawa, S, Miyasaka, N

Biochem Biophys Res Commun 1999
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