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IL12RB2:JAK2

Stable Identifier
R-HSA-8950039
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Inferred from mouse and muse-human protein interaction: There is experimental evidence that show that murine protein Tyrosin kinase Jak2(Jak2) (PMID: 9001223) associates with IL-12Rbeta2 (Interleukin-12 recetor subunit beta 2) directly and IL-12Rbeta1(Interleukin-12 recetor subunit beta 1) and Tyk2(Non-receptor tyrosine-protein kinase TYK2) are not required for the association between IL-12Rbeta2 and Jak2. (PMID:27193299)Stimulation with rhIL-12(recombinant human Interleukin-12) didn?t alter the association between IL-12Rbeta2 and Jak2 in COS 7 cells expressing IL-12Rbeta2, IL-12Rbeta1, Jak2 and Tyk2 (PMID:10198225) In conclusion the amino-terminus of Jak2 is necessary for association with IL-12Rbeta2. Thus Jak2 binds to the cytoplasmatic membrane-proximal region of IL-12Rbeta2, and box2 motif and tyrosine residues in the cytoplasmic domain are not required for binding (PMID:10198225)

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