Inferred from mouse and muse-human protein interaction: There is experimental evidence that show that murine protein Tyrosin kinase Jak2(Jak2) (PMID: 9001223) associates with IL-12Rbeta2 (Interleukin-12 recetor subunit beta 2) directly and IL-12Rbeta1(Interleukin-12 recetor subunit beta 1) and Tyk2(Non-receptor tyrosine-protein kinase TYK2) are not required for the association between IL-12Rbeta2 and Jak2. (PMID:27193299)Stimulation with rhIL-12(recombinant human Interleukin-12) didn’t alter the association between IL-12Rbeta2 and Jak2 in COS 7 cells expressing IL-12Rbeta2, IL-12Rbeta1, Jak2 and Tyk2 (PMID:10198225) In conclusion the amino-terminus of Jak2 is necessary for association with IL-12Rbeta2. Thus Jak2 binds to the cytoplasmatic membrane-proximal region of IL-12Rbeta2, and box2 motif and tyrosine residues in the cytoplasmic domain are not required for binding (PMID:10198225)
Lamertz, L, Floss, DM, Hermanns, H, Scheller, J, Schröder, J, Mrotzek, S, Strobl, B, Klöcker, T
Ihle, JN, Guschin, D, Stark, GR, Witthuhn, BA, Rogers, NC, Feng, J, Kohlhuber, F, Pestka, S, Briscoe, J, Kotenko, SV, Kerr, IM, Watling, D
Shibata, F, Kamiyama, R, Miyasaka, N, Hirosawa, S, Miura, O, Yamamoto, K
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