SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Stable Identifier
R-HSA-8949688
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NCLX catalyzes the exchange of 3-4 sodium ions from the intermembrane space for 1 calcium ion from the mitochondrial matrix (Palty et al. 2010, De Marchi et al. 2014). As a result, NCLX causes an efflux of calcium from the mitochondrial matrix and thereby attenuates calcium regulation of enzymatic activity within the mitochondrial matrix.

Literature References
PubMed ID Title Journal Year
24898248 NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state

De Marchi, U, Santo-Domingo, J, Castelbou, C, Sekler, I, Wiederkehr, A, Demaurex, N

J. Biol. Chem. 2014
20018762 NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

Palty, R, Silverman, WF, Hershfinkel, M, Caporale, T, Sensi, SL, Parnis, J, Nolte, C, Fishman, D, Shoshan-Barmatz, V, Herrmann, S, Khananshvili, D, Sekler, I

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Participates
Catalyst Activity

calcium:sodium antiporter activity of SLC8B1 [mitochondrial inner membrane]

Orthologous Events
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