Reactome | SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Stable Identifier

R-HSA-8949688

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

ReviewStatus

5/5

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SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

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NCLX catalyzes the exchange of 3-4 sodium ions from the intermembrane space for 1 calcium ion from the mitochondrial matrix (Palty et al. 2010, De Marchi et al. 2014). As a result, NCLX causes an efflux of calcium from the mitochondrial matrix and thereby attenuates calcium regulation of enzymatic activity within the mitochondrial matrix.

Literature References

PubMed ID	Title	Journal	Year
20018762	NCLX is an essential component of mitochondrial Na+/Ca2+ exchange Caporale, T, Khananshvili, D, Silverman, WF, Herrmann, S, Nolte, C, Fishman, D, Sensi, SL, Sekler, I, Palty, R, Parnis, J, Shoshan-Barmatz, V, Hershfinkel, M	Proc. Natl. Acad. Sci. U.S.A.	2010
24898248	NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state De Marchi, U, Castelbou, C, Sekler, I, Santo-Domingo, J, Wiederkehr, A, Demaurex, N	J. Biol. Chem.	2014