SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NCLX catalyzes the exchange of 3-4 sodium ions from the intermembrane space for 1 calcium ion from the mitochondrial matrix (Palty et al. 2010, De Marchi et al. 2014). As a result, NCLX causes an efflux of calcium from the mitochondrial matrix and thereby attenuates calcium regulation of enzymatic activity within the mitochondrial matrix.

Literature References
PubMed ID Title Journal Year
20018762 NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

Caporale, T, Khananshvili, D, Silverman, WF, Herrmann, S, Nolte, C, Fishman, D, Sensi, SL, Sekler, I, Palty, R, Parnis, J, Shoshan-Barmatz, V, Hershfinkel, M

Proc. Natl. Acad. Sci. U.S.A. 2010
24898248 NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state

De Marchi, U, Castelbou, C, Sekler, I, Santo-Domingo, J, Wiederkehr, A, Demaurex, N

J. Biol. Chem. 2014
Catalyst Activity

calcium:sodium antiporter activity of SLC8B1 [mitochondrial inner membrane]

Orthologous Events
Cite Us!