YME1L1 proteolyzes unassembled proSMDT1

Stable Identifier
R-HSA-8949668
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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ProSMDT1 (proEMRE) that is not bound by C2orf47:AFG3L2 and processed by PMPCA,B is proteolyzed by YME1L1 (Konig et al. 2016) in a large complex containing STOML2 (SLP2) and PARL (Wai et al. 2016). Thus YME1L1 appears to prevent accumulation of proSMDT1.

Literature References
PubMed ID Title Journal Year
27737933 The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L

Wai, T, Saita, S, Nolte, H, Müller, S, König, T, Richter-Dennerlein, R, Sprenger, HG, Madrenas, J, Mühlmeister, M, Brandt, U, Krüger, M, Langer, T

EMBO Rep. 2016
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

König, T, Tröder, SE, Bakka, K, Korwitz, A, Richter-Dennerlein, R, Lampe, PA, Patron, M, Mühlmeister, M, Guerrero-Castillo, S, Brandt, U, Decker, T, Lauria, I, Paggio, A, Rizzuto, R, Rugarli, EI, De Stefani, D, Langer, T

Mol. Cell 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of STOML2:PARL:YME1L [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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