YME1L1 proteolyzes unassembled proSMDT1

Stable Identifier
R-HSA-8949668
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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ProSMDT1 (proEMRE) that is not bound by C2orf47:AFG3L2 and processed by PMPCA,B is proteolyzed by YME1L1 (Konig et al. 2016) in a large complex containing STOML2 (SLP2) and PARL (Wai et al. 2016). Thus YME1L1 appears to prevent accumulation of proSMDT1.
Literature References
PubMed ID Title Journal Year
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

Bakka, K, König, T, Rizzuto, R, Guerrero-Castillo, S, Korwitz, A, Brandt, U, Langer, T, De Stefani, D, Tröder, SE, Lampe, PA, Rugarli, EI, Decker, T, Richter-Dennerlein, R, Lauria, I, Paggio, A, Mühlmeister, M, Patron, M

Mol. Cell 2016
27737933 The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L

König, T, Sprenger, HG, Richter-Dennerlein, R, Madrenas, J, Saita, S, Müller, S, Brandt, U, Nolte, H, Langer, T, Wai, T, Mühlmeister, M, Krüger, M

EMBO Rep. 2016
Participants
Participates
Catalyst Activity

metalloendopeptidase activity of STOML2:PARL:YME1L [mitochondrial inner membrane]

Orthologous Events
Authored
Reviewed
Created
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