YME1L1 proteolyzes unassembled proSMDT1

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ProSMDT1 (proEMRE) that is not bound by C2orf47:AFG3L2 and processed by PMPCA,B is proteolyzed by YME1L1 (Konig et al. 2016) in a large complex containing STOML2 (SLP2) and PARL (Wai et al. 2016). Thus YME1L1 appears to prevent accumulation of proSMDT1.

Literature References
PubMed ID Title Journal Year
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

Bakka, K, König, T, Rizzuto, R, Guerrero-Castillo, S, Korwitz, A, Brandt, U, Langer, T, De Stefani, D, Tröder, SE, Lampe, PA, Rugarli, EI, Decker, T, Richter-Dennerlein, R, Lauria, I, Paggio, A, Mühlmeister, M, Patron, M

Mol. Cell 2016
27737933 The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L

König, T, Sprenger, HG, Richter-Dennerlein, R, Madrenas, J, Saita, S, Müller, S, Brandt, U, Nolte, H, Langer, T, Wai, T, Mühlmeister, M, Krüger, M

EMBO Rep. 2016
Catalyst Activity

metalloendopeptidase activity of STOML2:PARL:YME1L [mitochondrial inner membrane]

Orthologous Events
Cite Us!