C2orf47:AFG3L2 binds the transit peptide of SMDT1

Stable Identifier
R-HSA-8949661
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

C2orf47 exists in a large complex containing AFG3L2 and SPG7, which exist in a large complex containing SPG7 (Paraplegin) in the mitochondrial matrix and binds the transit peptide of proSMDT1 (proEMRE). The binding stabilizes SMDT1 perhaps by preventing backsliding of SMDT1 into the intermembrane space (Konig et al. 2016).

Literature References
PubMed ID Title Journal Year
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

König, T, Tröder, SE, Bakka, K, Korwitz, A, Richter-Dennerlein, R, Lampe, PA, Patron, M, Mühlmeister, M, Guerrero-Castillo, S, Brandt, U, Decker, T, Lauria, I, Paggio, A, Rizzuto, R, Rugarli, EI, De Stefani, D, Langer, T

Mol. Cell 2016
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!