C2orf47:AFG3L2 binds the transit peptide of SMDT1

Stable Identifier
R-HSA-8949661
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
ReviewStatus
5/5
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C2orf47:AFG3L2 binds the transit peptide of SMDT1
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C2orf47 exists in a large complex containing AFG3L2 and SPG7, which exist in a large complex containing SPG7 (Paraplegin) in the mitochondrial matrix and binds the transit peptide of proSMDT1 (proEMRE). The binding stabilizes SMDT1 perhaps by preventing backsliding of SMDT1 into the intermembrane space (Konig et al. 2016).
Literature References
PubMed ID Title Journal Year
27642048 The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

König, T, Tröder, SE, Bakka, K, Korwitz, A, Richter-Dennerlein, R, Lampe, PA, Patron, M, Mühlmeister, M, Guerrero-Castillo, S, Brandt, U, Decker, T, Lauria, I, Paggio, A, Rizzuto, R, Rugarli, EI, De Stefani, D, Langer, T

Mol. Cell 2016
Participants
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Output
Participates
as an event of
Orthologous Events
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Bos taurus)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Caenorhabditis elegans)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Canis familiaris)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Danio rerio)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Drosophila melanogaster)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Gallus gallus)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Mus musculus)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Rattus norvegicus)
C2orf47:AFG3L2 binds the transit peptide of SMDT1 (Sus scrofa)
Authored
May, B  (2016-11-28)
Reviewed
Drago, I  (2017-01-21)
Created
May, B  (2016-11-28)
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