Reactome | Cristae formation

Cristae formation

Stable Identifier

R-HSA-8949613

DOI

10.3180/R-HSA-8949613.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Cristae are invaginations of the inner mitochondrial membrane that extend into the matrix and are lined with cytochrome complexes and F1Fo ATP synthase complexes. Cristae increase the surface area of the inner membranes allowing greater numbers of respiratory complexes. Cristae are also believed to serve as "proton pockets" to generate localized regions of higher membrane potential. The steps in the biogenesis of cristae are not yet completely elucidated (reviewed in Zick et al. 2009) but the formation of the Mitochondrial Contact Site and Cristae Organizing System (MICOS, formerly also known as MINOS, reviewed in Rampelt et al. 2016, Kozjak-Pavlovic 2016, van der Laan et al. 2016) and localized concentrations of cardiolipin are known to define the inward curvature of the inner membrane at the bases of cristae. MICOS also links these regions of the inner membrane with complexes (the SAM complex and, in fungi, the TOM complex) embedded in the outer membrane. CHCHD3 (MIC19) and IMMT (MIC60) subunits of MICOS also interact with OPA1 at the inner membrane (Darshi et al. 2011, Glytsou et al. 2016).
Formation of dimers or oligomers of the F1Fo ATP synthase complex causes extreme curvature of the inner membrane at the apices of cristae (reviewed in Seelert and Dencher 2011, Habersetzer et al. 2013). Defects in either MICOS or F1Fo ATP synthase oligomerization produce abnormal mitochondrial morphologies.

Literature References

PubMed ID	Title	Journal	Year
27245231	The MICOS complex of human mitochondria Kozjak-Pavlovic, V	Cell Tissue Res.	2016
22664329	ATP synthase oligomerization: from the enzyme models to the mitochondrial morphology Habersetzer, J, Ziani, W, Larrieu, I, Stines-Chaumeil, C, Giraud, MF, Brèthes, D, Dautant, A, Paumard, P	Int. J. Biochem. Cell Biol.	2013
27614134	Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics Rampelt, H, Zerbes, RM, van der Laan, M, Pfanner, N	Biochim. Biophys. Acta	2016
21081504	ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function Darshi, M, Mendiola, VL, Mackey, MR, Murphy, AN, Koller, A, Perkins, GA, Ellisman, MH, Taylor, SS	J. Biol. Chem.	2011
18620004	Cristae formation-linking ultrastructure and function of mitochondria Zick, M, Rabl, R, Reichert, AS	Biochim. Biophys. Acta	2009
21679683	ATP synthase superassemblies in animals and plants: two or more are better Seelert, H, Dencher, NA	Biochim. Biophys. Acta	2011
27062547	Mitochondrial contact site and cristae organizing system van der Laan, M, Horvath, SE, Pfanner, N	Curr. Opin. Cell Biol.	2016
27974214	Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control Glytsou, C, Calvo, E, Cogliati, S, Mehrotra, A, Anastasia, I, Rigoni, G, Raimondi, A, Shintani, N, Loureiro, M, Vázquez, J, Pellegrini, L, Enríquez, JA, Scorrano, L, Soriano, ME	Cell Rep	2016