F1Fo ATP synthase dimerizes

Stable Identifier
R-HSA-8949580
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
F1Fo ATP synthase binds F1Fo ATP synthase
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial membrane, an F1Fo ATP synthase complex binds another F1Fo ATP synthase complex to form a dimer that causes curvature of the inner mitochondrial membrane at internal regions of cristae (Habersetzer et al. 2013, inferred from bovine homologs in Strauss et al. 2008, Davies et al. 2011, Davies et al. 2012, inferred from yeast homologs in Arnold et al. 1998, Couoh-Cardel et al. 2010). The dimers are observed in rows along the highly curved apices of cristae (inferred from bovine homologs in Davies et al. 2014).

Literature References
PubMed ID Title Journal Year
24098383 Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter?

Habersetzer, J, Larrieu, I, Priault, M, Salin, B, Rossignol, R, Brèthes, D, Paumard, P

PLoS ONE 2013
18323778 Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

Strauss, M, Hofhaus, G, Schröder, RR, Kühlbrandt, W

EMBO J. 2008
20833715 Structure of dimeric F1F0-ATP synthase

Couoh-Cardel, SJ, Uribe-Carvajal, S, Wilkens, S, García-Trejo, JJ

J. Biol. Chem. 2010
25285856 Visualization of ATP synthase dimers in mitochondria by electron cryo-tomography

Davies, KM, Daum, B, Gold, VA, Mühleip, AW, Brandt, T, Blum, TB, Mills, DJ, Kühlbrandt, W

J Vis Exp 2014
22864911 Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

Davies, KM, Anselmi, C, Wittig, I, Faraldo-Gómez, JD, Kühlbrandt, W

Proc. Natl. Acad. Sci. U.S.A. 2012
17121862 ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization

Cortés-Hernández, P, Vázquez-Memije, ME, García, JJ

J. Biol. Chem. 2007
21836051 Macromolecular organization of ATP synthase and complex I in whole mitochondria

Davies, KM, Strauss, M, Daum, B, Kief, JH, Osiewacz, HD, Rycovska, A, Zickermann, V, Kühlbrandt, W

Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!