F1Fo ATP synthase dimerizes

Stable Identifier
Reaction [binding]
Homo sapiens
F1Fo ATP synthase binds F1Fo ATP synthase
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At the inner mitochondrial membrane, an F1Fo ATP synthase complex binds another F1Fo ATP synthase complex to form a dimer that causes curvature of the inner mitochondrial membrane at internal regions of cristae (Habersetzer et al. 2013, inferred from bovine homologs in Strauss et al. 2008, Davies et al. 2011, Davies et al. 2012, inferred from yeast homologs in Arnold et al. 1998, Couoh-Cardel et al. 2010). The dimers are observed in rows along the highly curved apices of cristae (inferred from bovine homologs in Davies et al. 2014).
Literature References
PubMed ID Title Journal Year
18323778 Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

Schröder, RR, Kühlbrandt, W, Hofhaus, G, Strauss, M

EMBO J. 2008
24098383 Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter?

Paumard, P, Salin, B, Priault, M, Rossignol, R, Habersetzer, J, Larrieu, I, Brèthes, D

PLoS ONE 2013
20833715 Structure of dimeric F1F0-ATP synthase

García-Trejo, JJ, Wilkens, S, Uribe-Carvajal, S, Couoh-Cardel, SJ

J. Biol. Chem. 2010
25285856 Visualization of ATP synthase dimers in mitochondria by electron cryo-tomography

Daum, B, Brandt, T, Mühleip, AW, Gold, VA, Kühlbrandt, W, Blum, TB, Davies, KM, Mills, DJ

J Vis Exp 2014
22864911 Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

Wittig, I, Anselmi, C, Kühlbrandt, W, Davies, KM, Faraldo-Gómez, JD

Proc. Natl. Acad. Sci. U.S.A. 2012
17121862 ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization

García, JJ, Cortés-Hernández, P, Vázquez-Memije, ME

J. Biol. Chem. 2007
21836051 Macromolecular organization of ATP synthase and complex I in whole mitochondria

Osiewacz, HD, Daum, B, Kief, JH, Kühlbrandt, W, Rycovska, A, Davies, KM, Zickermann, V, Strauss, M

Proc. Natl. Acad. Sci. U.S.A. 2011
Orthologous Events
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