Transcription of the ITGAL (CD11a) gene, is stimulated by binding of RUNX3, presumably in complex with CBFB, to the ITGAL promoter. ITGAL is a leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells. RUNX3, as well as RUNX1, positively regulate integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct regulation by RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).
Domínguez-Soto, A, Relloso, M, Vega, MA, Corbí, AL, Puig-Kröger, A
Puig-Kröger, A, Sanchez-Elsner, T, Ruiz, N, Andreu, EJ, Prosper, F, Jensen, UB, Gil, J, Erickson, P, Drabkin, H, Groner, Y, Corbí, AL
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