ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB

Stable Identifier
R-HSA-8949343
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Transcription of the ITGAL (CD11a) gene, is stimulated by binding of RUNX3, presumably in complex with CBFB, to the ITGAL promoter. ITGAL is a leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells. RUNX3, as well as RUNX1, positively regulate integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct regulation by RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).
Literature References
PubMed ID Title Journal Year
12855590 RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements

Puig-Kröger, A, Sanchez-Elsner, T, Ruiz, N, Andreu, EJ, Prosper, F, Jensen, UB, Gil, J, Erickson, P, Drabkin, H, Groner, Y, Corbí, AL

Blood 2003
16164020 RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters

Domínguez-Soto, A, Relloso, M, Vega, MA, Corbí, AL, Puig-Kröger, A

Immunobiology 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX3:CBFB:ITGAL gene,(ITGA4 gene) [nucleoplasm] (Homo sapiens)
Active Unit
RUNX3:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-11-22)
Cite Us!