ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB

Stable Identifier
R-HSA-8949343
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB
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Transcription of the ITGAL (CD11a) gene, is stimulated by binding of RUNX3, presumably in complex with CBFB, to the ITGAL promoter. ITGAL is a leukocyte integrin involved in transendothelial migration of leukocytes during immune and inflammatory responses as well as co-stimulation of T cells. RUNX3, as well as RUNX1, positively regulate integrin alpha 4 (ITGA4, also known as CD49d) expression. A RUNX binding site exists in the ITGA4 promoter, but the direct regulation by RUNX transcription factors has not been demonstrated (Domniguez-Soto et al. 2005).
Literature References
PubMed ID Title Journal Year
12855590 RUNX/AML and C/EBP factors regulate CD11a integrin expression in myeloid cells through overlapping regulatory elements

Corbí, AL, Ruiz, N, Erickson, P, Andreu, EJ, Sanchez-Elsner, T, Puig-Kröger, A, Groner, Y, Prosper, F, Gil, J, Jensen, UB, Drabkin, H

Blood 2003
16164020 RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters

Corbí, AL, Puig-Kröger, A, Relloso, M, Vega, MA, Domínguez-Soto, A

Immunobiology 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX3:CBFB:ITGAL gene,(ITGA4 gene) [nucleoplasm] (Homo sapiens)
Active Unit
RUNX3:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-11-22)
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