Reactome | MCU [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949184

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

fullName evidence="30"Calcium uniporter protein, mitochondrial, MCU_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NE86 MCU

Gene Names

MCU, C10orf42, CCDC109A

Chain

transit peptide:1-50, chain:51-351

Reference Genes

COSMIC (genes):MCU MCU

dbSNP Gene:90550 MCU

ENSEMBL:ENSG00000156026 MCU

Participates

as an input of

as a component of

Inferred To

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4I9 SMDT1	3	SMDT1 transit peptide [mitochondrial matrix] (R-HSA-8949642) proSMDT1 [mitochondrial inner membrane] (R-HSA-8949655) SMDT1 [mitochondrial inner membrane] (R-HSA-8949227)	0.763	9
UniProt:Q9BPX6 MICU1	1	MICU1 [mitochondrial inner membrane] (R-HSA-8949180)	0.739	7
UniProt:Q8NFQ8 TOIP2			0.527	3
UniProt:P46059 SLC15A1	1	SLC15A1 [plasma membrane] (R-HSA-428022)	0.527	2
UniProt:Q8IYU8 MICU2	1	MICU2 [mitochondrial inner membrane] (R-HSA-8949166)	0.527	3
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.527	2
UniProt:Q12797 ASPH	2	ASPH [endoplasmic reticulum lumen] (R-HSA-9631383) ASPH [endoplasmic reticulum membrane] (R-HSA-5490331)	0.527	3
UniProt:Q6NXR0 IIGP5			0.527	2
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.527	2
UniProt:Q8N695 SLC5A8	1	SLC5A8 [plasma membrane] (R-HSA-429769)	0.527	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2

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