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MCU [mitochondrial inner membrane]
Stable Identifier
R-HSA-8949184
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
fullName evidence="30"Calcium uniporter protein, mitochondrial, MCU_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Mitochondrial calcium ion transport (Homo sapiens)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
MCU complex [mitochondrial inner membrane] (Homo sapiens)
MCU [mitochondrial inner membrane] (Homo sapiens)
Processing of SMDT1 (Homo sapiens)
SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)
MCU [mitochondrial inner membrane] (Homo sapiens)
MCU complex [mitochondrial inner membrane] (Homo sapiens)
MCU [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NE86 MCU
Gene Names
MCU, C10orf42, CCDC109A
Chain
transit peptide:1-50, chain:51-351
Reference Genes
BioGPS Gene:90550 MCU
COSMIC (genes):MCU MCU
CTD Gene:90550 MCU
dbSNP Gene:90550 MCU
ENSEMBL:ENSG00000156026 MCU
HGNC:23526 MCU
KEGG Gene (Homo sapiens):90550 MCU
Monarch:90550 MCU
NCBI Gene:90550 MCU
OMIM:614197 MCU
UCSC:Q8NE86 MCU
Reference Transcript
RefSeq:NM_001270679.1 MCU
RefSeq:NM_001270680.1 MCU
RefSeq:NM_138357.2 MCU
Other Identifiers
0000510592
11737773_a_at
11749065_a_at
16705976
225320_at
3251495
3251496
3251497
3251498
3251536
3251543
3251545
3251546
3251547
3251548
3251551
3251552
3251553
3251554
3251555
52971_at
62911_at
7928318
90550
A_14_P128543
A_23_P346405
GE87133
GO:0002376
GO:0003674
GO:0005262
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005743
GO:0006810
GO:0006811
GO:0006816
GO:0006851
GO:0007005
GO:0007010
GO:0007165
GO:0007267
GO:0008150
GO:0015031
GO:0015292
GO:0016020
GO:0016021
GO:0019722
GO:0022607
GO:0022857
GO:0031305
GO:0032024
GO:0032991
GO:0034704
GO:0036444
GO:0040011
GO:0042592
GO:0042593
GO:0042802
GO:0043226
GO:0048856
GO:0048870
GO:0051259
GO:0051560
GO:0051561
GO:0055085
GO:0065003
GO:0070588
GO:0090023
GO:0090141
GO:0090527
GO:1990246
HMNXSV003014441
Hs.4896.0.A1_3p_at
ILMN_1672759
PH_hs_0000498
TC10000452.hg
Participates
as an input of
SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)
as a component of
MCU complex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
MCU [mitochondrial inner membrane]
(Canis familiaris)
MCU [mitochondrial inner membrane]
(Dictyostelium discoideum)
MCU [mitochondrial inner membrane]
(Drosophila melanogaster)
MCU [mitochondrial inner membrane]
(Gallus gallus)
MCU [mitochondrial inner membrane]
(Sus scrofa)
Mcu [mitochondrial inner membrane]
(Mus musculus)
Mcu [mitochondrial inner membrane]
(Rattus norvegicus)
nkx2-2 [mitochondrial inner membrane]
(Xenopus tropicalis)
mcu-1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
mcu [mitochondrial inner membrane]
(Danio rerio)
Cross References
RefSeq
NP_001257608.1
,
NP_001257609.1
,
NP_612366.1
OpenTargets
ENSG00000156026
GeneCards
Q8NE86
HPA
ENSG00000156026-MCU
Ensembl
ENSG00000156026
,
ENSP00000349680
,
ENSP00000362144
,
ENSP00000440913
,
ENST00000536019
,
ENST00000357157
,
ENST00000373053
PRO
Q8NE86
Pharos - Targets
Q8NE86
GlyGen
Q8NE86
PDB
6O5B
,
6K7X
,
5KUE
,
5BZ6
,
6JG0
,
6K7Y
,
4XSJ
,
6XJX
,
5KUG
,
4XTB
,
5KUJ
,
6O58
,
6XJV
,
5KUI
,
6WDN
,
6KVX
,
6WDO
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BPX6 MICU1
1
MICU1 [mitochondrial inner membrane]
(R-HSA-8949180)
0.739
7
UniProt:Q9H4I9 SMDT1
3
SMDT1 [mitochondrial inner membrane]
(R-HSA-8949227)
proSMDT1 [mitochondrial inner membrane]
(R-HSA-8949655)
SMDT1 transit peptide [mitochondrial matrix]
(R-HSA-8949642)
0.693
8
UniProt:Q8IYU8 MICU2
1
MICU2 [mitochondrial inner membrane]
(R-HSA-8949166)
0.527
3
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