Reactome | MCU [mitochondrial inner membrane]

MCU [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949184

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

fullName evidence="30"Calcium uniporter protein, mitochondrial, MCU_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8NE86 MCU

Gene Names

MCU, C10orf42, CCDC109A

Chain

transit peptide:1-50, chain:51-351

Reference Genes

BioGPS Gene:90550 MCU

COSMIC (genes):MCU MCU

CTD Gene:90550 MCU

dbSNP Gene:90550 MCU

ENSEMBL:ENSG00000156026 MCU

HGNC:23526 MCU

KEGG:hsa:90550 MCU

Monarch:90550 MCU

NCBI Gene:90550 MCU

OMIM:614197 MCU

UCSC:Q8NE86 MCU

Reference Transcript

Participates

as an input of

SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)

as a component of

MCU complex [mitochondrial inner membrane] (Homo sapiens)

Inferred To

MCU [mitochondrial inner membrane] (Bos taurus)

MCU [mitochondrial inner membrane] (Canis familiaris)

MCU [mitochondrial inner membrane] (Drosophila melanogaster)

MCU [mitochondrial inner membrane] (Gallus gallus)

MCU [mitochondrial inner membrane] (Sus scrofa)

Mcu [mitochondrial inner membrane] (Mus musculus)

Mcu [mitochondrial inner membrane] (Rattus norvegicus)

mcu-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

mcu [mitochondrial inner membrane] (Danio rerio)

mcu [mitochondrial inner membrane] (Dictyostelium discoideum)

mcu [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_612366.1, NP_001257609.1, NP_001257608.1

OpenTargets

ENSG00000156026

ENSEMBL

ENSP00000440913, ENST00000357157, ENSP00000349680, ENSP00000362144, ENSG00000156026, ENST00000373053, ENST00000536019

HPA

ENSG00000156026-MCU

GeneCards

MCU

PRO

Q8NE86

Pharos - Targets

Q8NE86

GlyGen

Q8NE86

PDB

6WDN, 5KUI, 6O5B, 4XTB, 5KUJ, 5KUE, 6WDO, 6XJX, 8URG, 4XSJ, 5BZ6, 5KUG, 6JG0, 6O58, 6KVX, 6K7X, 6K7Y, 6XJV

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4I9 SMDT1	3	SMDT1 [mitochondrial inner membrane] (R-HSA-8949227) proSMDT1 [mitochondrial inner membrane] (R-HSA-8949655) SMDT1 transit peptide [mitochondrial matrix] (R-HSA-8949642)	0.763	9
UniProt:Q9BPX6 MICU1	1	MICU1 [mitochondrial inner membrane] (R-HSA-8949180)	0.739	7
UniProt:Q12797 ASPH	2	ASPH [endoplasmic reticulum membrane] (R-HSA-5490331) ASPH [endoplasmic reticulum lumen] (R-HSA-9631383)	0.643	4
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.527	2
UniProt:Q6NXR0 IIGP5			0.527	2
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:Q8IYU8 MICU2	1	MICU2 [mitochondrial inner membrane] (R-HSA-8949166)	0.527	3
UniProt:Q8N695 SLC5A8	1	SLC5A8 [plasma membrane] (R-HSA-429769)	0.527	2
UniProt:P46059 SLC15A1	1	SLC15A1 [plasma membrane] (R-HSA-428022)	0.527	2
UniProt:Q8NFQ8 TOIP2			0.527	3

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