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MICU1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-8949180
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Calcium uptake protein 1, mitochondrial, MICU1_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Mitochondrial calcium ion transport (Homo sapiens)
MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
MCU complex [mitochondrial inner membrane] (Homo sapiens)
MICU1 [mitochondrial inner membrane] (Homo sapiens)
Processing of SMDT1 (Homo sapiens)
SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)
MCU complex [mitochondrial inner membrane] (Homo sapiens)
MICU1 [mitochondrial inner membrane] (Homo sapiens)
MICU1 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BPX6 MICU1
Gene Names
MICU1, CALC, CBARA1
Chain
transit peptide:1-33, chain:34-476
Reference Genes
BioGPS Gene:10367 MICU1
COSMIC (genes):MICU1 MICU1
CTD Gene:10367 MICU1
dbSNP Gene:10367 MICU1
ENSEMBL:ENSG00000107745 MICU1
ENSEMBL_homo_sapiens_GENE:ENSG00000107745.20 MICU1
HGNC:1530 MICU1
KEGG Gene (Homo sapiens):10367 MICU1
Monarch:10367 MICU1
NCBI Gene:10367 MICU1
OMIM:605084 MICU1
UCSC:Q9BPX6 MICU1
Reference Transcript
RefSeq:NM_006077.3 MICU1
RefSeq:NM_001195518.1 MICU1
RefSeq:NM_001195519.1 MICU1
Other Identifiers
10367
11749321_a_at
11758646_s_at
16715331
216903_PM_s_at
216903_s_at
3293999
3294000
3294002
3294009
3294015
3294016
3294030
3294031
3294032
3294036
3294044
3294050
3294051
3294054
3294055
3294056
3294065
3294066
3294067
35360_at
51701_at
7934255
A_23_P46907
GE56462
GO:0005509
GO:0005515
GO:0005739
GO:0005743
GO:0005758
GO:0006811
GO:0006816
GO:0006851
GO:0006952
GO:0016020
GO:0031966
GO:0034704
GO:0036444
GO:0042802
GO:0043226
GO:0046872
GO:0046982
GO:0051260
GO:0051560
GO:0051561
GO:0055065
GO:0055085
GO:0065003
GO:0070509
GO:1900069
GO:1990246
HMNXSV003020447
HMNXSV003035102
Hs.61628.1.A1_3p_a_at
ILMN_1807540
PH_hs_0003917
TC10001394.hg
Participates
as an input of
SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)
as a component of
MCU complex [mitochondrial inner membrane] (Homo sapiens)
Inferred To
MICU1 [mitochondrial inner membrane]
(Bos taurus)
MICU1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
MICU1 [mitochondrial inner membrane]
(Canis familiaris)
MICU1 [mitochondrial inner membrane]
(Dictyostelium discoideum)
MICU1 [mitochondrial inner membrane]
(Drosophila melanogaster)
MICU1 [mitochondrial inner membrane]
(Gallus gallus)
MICU1 [mitochondrial inner membrane]
(Mus musculus)
MICU1 [mitochondrial inner membrane]
(Rattus norvegicus)
MICU1 [mitochondrial inner membrane]
(Sus scrofa)
MICU1 [mitochondrial inner membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001182448.1
,
NP_001182447.1
,
NP_006068.2
OpenTargets
ENSG00000107745
HPA
ENSG00000107745-MICU1
GeneCards
Q9BPX6
Ensembl
ENSP00000402470
,
ENSP00000354415
,
ENST00000418483
,
ENST00000398763
,
ENST00000361114
,
ENSP00000381747
,
ENSG00000107745
PRO
Q9BPX6
Pharos - Targets
Q9BPX6
Orphanet
22894
PDB
6XQN
,
6WDN
,
6XJX
,
6K7Y
,
4NSD
,
6LE5
,
6XJV
,
6LB8
,
6WDO
,
6LB7
,
6XQO
,
4NSC
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NE86 MCU
1
MCU [mitochondrial inner membrane]
(R-HSA-8949184)
0.739
7
UniProt:Q8IYU8 MICU2
1
MICU2 [mitochondrial inner membrane]
(R-HSA-8949166)
0.723
8
UniProt:Q8NE86-1 MCU
0.589
2
UniProt:Q8N4Q1 CHCHD4
1
CHCHD4 [mitochondrial intermembrane space]
(R-HSA-1252140)
0.576
6
UniProt:Q9BPX6 MICU1
1
MICU1 [mitochondrial inner membrane]
(R-HSA-8949180)
0.558
8
UniProt:Q9H4I9 SMDT1
3
SMDT1 transit peptide [mitochondrial matrix]
(R-HSA-8949642)
SMDT1 [mitochondrial inner membrane]
(R-HSA-8949227)
proSMDT1 [mitochondrial inner membrane]
(R-HSA-8949655)
0.488
3
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