MCU complex [mitochondrial inner membrane]

Stable Identifier
R-HSA-8949151
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
Mitochondrial Calcium Uniporter
Literature References
PubMed ID Title Journal Year
27184846 MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

Caplan, J, Dietrich, A, Shanmughapriya, S, Fairweather, JP, Jaña, F, Goldman, SJ, Breves, SL, Elrod, JW, Huang, J, Stathopulos, P, Merali, S, Barrero, C, Koch, DA, Patel, V, Rajan, S, Houser, SR, Zhang, X, Timbalia, SA, Thomas, T, Schumacher, SM, Tomar, D, Luongo, TS, Corbally, DP, Cutri, AR, Ahima, RS, Rockman, ME, Hoffman, NE, Madesh, M, Gohil, VM, Song, J, Koch, WJ, Dong, Z, Cheung, JY, Nemani, N, Rabinowitz, JE

Cell Rep 2016
25565209 CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter

Prudent, J, Paupe, V, Rendon, OZ, Shoubridge, EA, Dassa, EP

Cell Metab. 2015
23409044 MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

Speciner, L, Koteliansky, V, Bogorad, RL, Taneja, N, Girgis, HS, De Groot, J, Strittmatter, L, Mootha, VK, Plovanich, M, Oshea, J, Sancak, Y, Kamer, KJ, Kuchimanchi, S, Li, AA

PLoS ONE 2013
23178883 MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

Cárdenas, C, Müller, M, Golenár, T, Miller, R, Madesh, M, Foskett, JK, Kolesar, JE, Mallilankaraman, K, Yang, J, Doonan, PJ, Madireddi, P, Irrinki, KM, Chandramoorthy, HC, Molgó, J, Csordás, G, Kaufman, B, Hajnóczky, G

Nat. Cell Biol. 2012
21685886 Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Goldberger, O, Belcher-Timme, CA, Sancak, Y, Koteliansky, V, Baughman, JM, Bogorad, RL, Bao, XR, Perocchi, F, Girgis, HS, Strittmatter, L, Mootha, VK, Plovanich, M

Nature 2011
21685888 A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Szabò, I, Rizzuto, R, Teardo, E, Raffaello, A, De Stefani, D

Nature 2011
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