TNKS and TNKS2 PARylate PTEN

Stable Identifier
R-HSA-8948800
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PTEN can bind tankyrases TNKS (TNKS1) and TNKS2. The interaction involves the tankyrase binding motif at the N-terminus of PTEN (RYQEDG). TNKS and TNKS2 poly-ADP-ribosylate (PARylate) PTEN on glutamic acid residues E40 and E150 and on aspartic acid residue D326. PTEN PARylation is a pre-requisite for RNF146-mediated ubiquitination of PTEN (Li et al. 2015).

Literature References
PubMed ID Title Journal Year
25547115 Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

Li, N, Zhang, Y, Han, X, Liang, K, Wang, J, Feng, L, Wang, W, Songyang, Z, Lin, C, Yang, L, Yu, Y, Chen, J

Genes Dev. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
NAD+ ADP-ribosyltransferase activity of TNKS1/2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created