Reactome | TNKS and TNKS2 PARylate PTEN

TNKS and TNKS2 PARylate PTEN

Stable Identifier

R-HSA-8948800

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PTEN can bind tankyrases TNKS (TNKS1) and TNKS2. The interaction involves the tankyrase binding motif at the N-terminus of PTEN (RYQEDG). TNKS and TNKS2 poly-ADP-ribosylate (PARylate) PTEN on glutamic acid residues E40 and E150 and on aspartic acid residue D326. PTEN PARylation is a pre-requisite for RNF146-mediated ubiquitination of PTEN (Li et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25547115	Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth Yang, L, Lin, C, Wang, W, Li, N, Chen, J, Songyang, Z, Feng, L, Zhang, Y, Liang, K, Wang, J, Yu, Y, Han, X	Genes Dev.	2015