miR-17 microRNA binds CNOT6L mRNA

Stable Identifier
R-HSA-8948583
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
miR-17 microRNA binds CNOT6L mRNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MicroRNA miR-17 binds the CNOT6L mRNA. CNOT6L mRNA acts as a competing endogenous RNA (ceRNA) for PTEN, preventing binding of miR-17 microRNA to PTEN mRNA and PTEN downregulation (Tay et al. 2011).

Literature References
PubMed ID Title Journal Year
22000013 Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Tay, Y, Kats, L, Salmena, L, Weiss, D, Tan, SM, Ala, U, Karreth, F, Poliseno, L, Provero, P, Di Cunto, F, Lieberman, J, Rigoutsos, I, Pandolfi, PP

Cell 2011
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Salmena, L  (2016-08-11)
Created
Orlic-Milacic, M  (2016-11-15)
Cite Us!