MicroRNA miR-19b, encoded by two genomic loci, MIR19B1 and MIR19B2, is homologous to miR-19a and also binds to the 3'UTR of PTEN mRNA (Polseno, Salmena, Zhang et al. 2010). miR-19b microRNA causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-19b microRNA also functions as a part of the nonendonucleolytic RISC.
Pandolfi, PP, Carver, B, Haveman, WJ, Poliseno, L, Zhang, J, Salmena, L
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