PTENP1 mRNA binds miR-20 RISC

Stable Identifier
R-HSA-8948536
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PTENP1 mRNA binds miR-20 RISC
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PTENP1 mRNA is the product of the PTEN pseudogene PTENP1 and is highly homologous to PTEN mRNA. PTENP1 mRNA contains a perfect match for the miR-20 family of microRNAs, which target PTEN mRNA for degradation. miR-20a was shown to suppress both PTENP1 and PTEN transcript levels, and it is possible that miR-20b functions in a similar manner.
Overexpression of PTENP1 3'UTR results in de-repression of both PTEN mRNA and protein in the presence of mature PTEN-targeting microRNAs. Knockdown of PTENP1 decreases abundance of PTEN mRNA and protein. PTENP1 therefore functions as a competing endogenous RNA (ce-RNA) in microRNA-mediated PTEN regulation. PTENP1 losses have been reported in cancer (Poliseno et al. 2010).
Literature References
PubMed ID Title Journal Year
20577206 A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Pandolfi, PP, Carver, B, Haveman, WJ, Poliseno, L, Zhang, J, Salmena, L

Nature 2010
Participants
Input
Output
Participates
as an event of
Authored
Salmena, L  (2016-08-11)
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Created
Orlic-Milacic, M  (2016-11-14)
Cite Us!