PTENP1 mRNA binds miR-19b RISC

Stable Identifier
R-HSA-8948524
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTENP1 mRNA binds miR-19b RISC
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PTENP1 mRNA is the product of the PTEN pseudogene PTENP1 and is highly homologous to PTEN mRNA. PTENP1 mRNA contains a perfect match for the miR-19 family of microRNAs, which target PTEN mRNA for degradation. miR-19b was shown to suppress both PTENP1 and PTEN transcript levels.
Overexpression of PTENP1 3'UTR results in de-repression of both PTEN mRNA and protein in the presence of mature PTEN-targeting microRNAs. Knockdown of PTENP1 decreases abundance of PTEN mRNA and protein. PTENP1 therefore functions as a competing endogenous RNA (ce-RNA) in microRNA-mediated PTEN regulation. PTENP1 losses have been reported in cancer (Poliseno et al. 2010).
Literature References
PubMed ID Title Journal Year
20577206 A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Poliseno, L, Salmena, L, Zhang, J, Carver, B, Haveman, WJ, Pandolfi, PP

Nature 2010
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Authored
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Salmena, L  (2016-08-11)
Created
Orlic-Milacic, M  (2016-11-14)
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