PTENP1 mRNA binds miR-19b RISC

Stable Identifier
R-HSA-8948524
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PTENP1 mRNA is the product of the PTEN pseudogene PTENP1 and is highly homologous to PTEN mRNA. PTENP1 mRNA contains a perfect match for the miR-19 family of microRNAs, which target PTEN mRNA for degradation. miR-19b was shown to suppress both PTENP1 and PTEN transcript levels.
Overexpression of PTENP1 3'UTR results in de-repression of both PTEN mRNA and protein in the presence of mature PTEN-targeting microRNAs. Knockdown of PTENP1 decreases abundance of PTEN mRNA and protein. PTENP1 therefore functions as a competing endogenous RNA (ce-RNA) in microRNA-mediated PTEN regulation. PTENP1 losses have been reported in cancer (Poliseno et al. 2010).

Literature References
PubMed ID Title Journal Year
20577206 A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Poliseno, L, Salmena, L, Zhang, J, Carver, B, Haveman, WJ, Pandolfi, PP

Nature 2010
Participants
Participant Of
Authored