PLOD3 binds Lysyl hydroxylated collagen propeptides

Stable Identifier
R-HSA-8948219
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
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PLOD3 binds Lysyl hydroxylated collagen propeptides
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The ER membrane-associated enzyme PLOD3 has collagen galactosyltransferase activity (Heikkinen et al. 2000, Wang et al. 2002), though whether it physiologically relevant has been questioned (Schegg et al. 2009).

Literature References
PubMed ID Title Journal Year
10934207 Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity

Heikkinen, J, Risteli, M, Wang, C, Latvala, J, Rossi, M, Valtavaara, M, Myllylä, R

J Biol Chem 2000
12475640 The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro

Wang, C, Luosujärvi, H, Heikkinen, J, Risteli, M, Uitto, L, Myllylä, R

Matrix Biol 2002
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Orthologous Events
PLOD3 binds Lysyl hydroxylated collagen propeptides (Danio rerio)
PLOD3 binds Lysyl hydroxylated collagen propeptides (Mus musculus)
PLOD3 binds Lysyl hydroxylated collagen propeptides (Rattus norvegicus)
PLOD3 binds Lysyl hydroxylated collagen propeptides (Sus scrofa)
PLOD3 binds Lysyl hydroxylated collagen propeptides (Xenopus tropicalis)
Authored
Jupe, S  (2012-04-11)
Reviewed
Canty-Laird, EG  (2012-05-24)
Created
Jupe, S  (2016-11-11)
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