FUNDC1 is phosphorylated by ULK1 at Ser17

Stable Identifier
R-HSA-8948146
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to LC3. FUNDC1 regulates ULK1 recruitment to damaged mitochondria; FUNDC1 phosphorylation by ULK1 is crucial for mitophagy.

Literature References
PubMed ID Title Journal Year
24671035 ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

Wu, W, Tian, W, Hu, Z, Chen, G, Huang, L, Li, W, Zhang, X, Xue, P, Zhou, C, Liu, L, Zhu, Y, Zhang, X, Li, L, Zhang, L, Sui, S, Zhao, B, Feng, D

EMBO Rep. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of ULK1 [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created