ULK1 Translocates to the mitochondria

Stable Identifier
R-HSA-8948136
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ULK1 is critical for the induction of autophagy, translocating to fragmented mitochondria upon mitophagy induction by either hypoxia or mitochondrial uncouplers. At mitochondria, ULK1 interacts with FUNDC1.

Literature References
PubMed ID Title Journal Year
24671035 ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

Wu, W, Tian, W, Hu, Z, Chen, G, Huang, L, Li, W, Zhang, X, Xue, P, Zhou, C, Liu, L, Zhu, Y, Zhang, X, Li, L, Zhang, L, Sui, S, Zhao, B, Feng, D

EMBO Rep. 2014
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