Reactome | FUNDC1 is phosphorylated by CK2

FUNDC1 is phosphorylated by CK2

Stable Identifier

R-HSA-8948039

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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FUNDC1-mediated mitophagy is inhibited by its phosphorylation at the Serine 13 positions in the LIR motif by CK2kinase under normoxia conditions. These phosphorylation events insure that FUNDC1 cannot bind LC3.

Literature References

PubMed ID	Title	Journal	Year
24746696	A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy Cai, X, Feng, D, Chen, Q, Chen, Y, Han, Z, Chen, L, Duan, L, Fu, C, Huang, L, Wang, X, Liu, X, Liu, L, Wu, H, Shen, Y, Zhou, C, Zhu, Y, Chen, G	Mol. Cell	2014