hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb

Stable Identifier
R-HSA-8948015
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated ubiquitin is transferred to a heterodimeric E2 conjugating enzyme UBE2N (Ubc13) and UBEE2V1 (Uev1A) forming an E2-Ub thioester.

Literature References
PubMed ID Title Journal Year
17135271 Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

Lamothe, B, Besse, A, Campos, AD, Webster, WK, Wu, H, Darnay, BG

J Biol Chem 2007
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Danio rerio)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Rattus norvegicus)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-09-06)
Created
Jupe, S  (2016-11-08)
Cite Us!