hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb

Stable Identifier
R-HSA-8948015
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb
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Activated ubiquitin is transferred to a heterodimeric E2 conjugating enzyme UBE2N (Ubc13) and UBEE2V1 (Uev1A) forming an E2-Ub thioester.

Literature References
PubMed ID Title Journal Year
17135271 Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

Lamothe, B, Wu, H, Darnay, BG, Besse, A, Campos, AD, Webster, WK

J Biol Chem 2007
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Orthologous Events
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Danio rerio)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Dictyostelium discoideum)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Drosophila melanogaster)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Mus musculus)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Rattus norvegicus)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Sus scrofa)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-09-06)
Created
Jupe, S  (2016-11-08)
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