MicroRNA miR-205-5p, one of the two mature products of miR-205, binds the 3'UTR of the PTEN mRNA, resulting in downregulation of PTEN mRNA and protein levels. miR-205 functions as part of both endonucleolytic and nonendonucleolytic RISCs (Qu et al. 2012, Cai et al. 2013). In addition to PTEN, miR-205 targets another negative regulator of PI3K/AKT signaling - the protein serine/threonine phosphatase PHLPP2 (Cai et al. 2013).
Cai, J, Huang, Y, Li, R, Yang, Y, Yuan, J, Fang, L, Li, M, Chen, B, Zhu, X, Wu, J
Liang, Z, Zhang, R, Huang, J, Wang, X, Su, C, Qu, C, Lee, MH, Zhao, R, Wang, S, Yang, H
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