miR-205 microRNA binds PTEN mRNA

Stable Identifier
R-HSA-8944684
Type
Reaction [binding]
Species
Homo sapiens
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MicroRNA miR-205-5p, one of the two mature products of miR-205, binds the 3'UTR of the PTEN mRNA, resulting in downregulation of PTEN mRNA and protein levels. miR-205 functions as part of both endonucleolytic and nonendonucleolytic RISCs (Qu et al. 2012, Cai et al. 2013). In addition to PTEN, miR-205 targets another negative regulator of PI3K/AKT signaling - the protein serine/threonine phosphatase PHLPP2 (Cai et al. 2013).

Literature References
PubMed ID Title Journal Year
22374676 MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN

Qu, C, Liang, Z, Huang, J, Zhao, R, Su, C, Wang, S, Wang, X, Zhang, R, Lee, MH, Yang, H

Cell Cycle 2012
23856247 miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer

Cai, J, Fang, L, Huang, Y, Li, R, Yuan, J, Yang, Y, Zhu, X, Chen, B, Wu, J, Li, M

Cancer Res. 2013
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