miR-106 microRNAs bind PTEN mRNA

Stable Identifier
R-HSA-8944632
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-106 microRNAs bind PTEN mRNA
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MicroRNA miR-106b-5p, one of the two mature products of miR-106b, binds the 3'UTR of PTEN mRNA (Poliseno et al. 2010). miR-106b causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-106b also functions as a part of the nonendonucleolytic RISC. MicroRNA miR-106a-5p, one of the two mature products of miR-106a, is homologous to miR-106b and binds to the 3'UTR of PTEN mRNA. miR-106a presumably functions in a manner similar to miR-106b (Tay et al. 2011).
Literature References
PubMed ID Title Journal Year
20388916 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

Poliseno, L, Salmena, L, Riccardi, L, Fornari, A, Song, MS, Hobbs, RM, Sportoletti, P, Varmeh, S, Egia, A, Fedele, G, Rameh, L, Loda, M, Pandolfi, PP

Sci Signal 2010
22000013 Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Tay, Y, Kats, L, Salmena, L, Weiss, D, Tan, SM, Ala, U, Karreth, F, Poliseno, L, Provero, P, Di Cunto, F, Lieberman, J, Rigoutsos, I, Pandolfi, PP

Cell 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
miR-106 RISC:VAPA mRNA [cytosol] (Homo sapiens)
Active Unit
VAPA mRNA [cytosol]
Regulator
miR-106 RISC:CNOT6L mRNA [cytosol] (Homo sapiens)
Active Unit
CNOT6L mRNA [cytosol]
Authored
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Salmena, L  (2016-08-11)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-04)
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