miR-106 microRNAs bind PTEN mRNA

Stable Identifier
R-HSA-8944632
Type
Reaction [binding]
Species
Homo sapiens
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MicroRNA miR-106b-5p, one of the two mature products of miR-106b, binds the 3'UTR of PTEN mRNA (Poliseno et al. 2010). miR-106b causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-106b also functions as a part of the nonendonucleolytic RISC. MicroRNA miR-106a-5p, one of the two mature products of miR-106a, is homologous to miR-106b and binds to the 3'UTR of PTEN mRNA. miR-106a presumably functions in a manner similar to miR-106b (Tay et al. 2011).

Literature References
PubMed ID Title Journal Year
22000013 Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Tay, Y, Kats, L, Salmena, L, Weiss, D, Tan, SM, Ala, U, Karreth, F, Poliseno, L, Provero, P, Di Cunto, F, Lieberman, J, Rigoutsos, I, Pandolfi, PP

Cell 2011
20388916 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

Poliseno, L, Salmena, L, Riccardi, L, Fornari, A, Song, MS, Hobbs, RM, Sportoletti, P, Varmeh, S, Egia, A, Fedele, G, Rameh, L, Loda, M, Pandolfi, PP

Sci Signal 2010
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