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miR-25 Endonucleolytic Minimal RISC [cytosol]
Stable Identifier
R-HSA-8944567
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
Argonaute2: miR-25 (single-stranded)
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN mRNA translation (Homo sapiens)
PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)
miR-25 RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-25 RISC:PTEN mRNA [cytosol] (Homo sapiens)
miR-25 RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-25 microRNA binds PTEN mRNA (Homo sapiens)
miR-25 RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
miR-25 RISC:PTEN mRNA [cytosol] (Homo sapiens)
miR-25 RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic RISC [cytosol] (Homo sapiens)
miR-25 Endonucleolytic Minimal RISC [cytosol] (Homo sapiens)
General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.
Participants
components
AGO2 [cytosol]
(Homo sapiens)
miR-25 [cytosol]
(Homo sapiens)
Participates
as a component of
miR-25 Endonucleolytic RISC [cytosol] (Homo sapiens)
Inferred To
miR-25 Endonucleolytic Minimal RISC [cytosol]
(Bos taurus)
miR-25 Endonucleolytic Minimal RISC [cytosol]
(Canis familiaris)
miR-25 Endonucleolytic Minimal RISC [cytosol]
(Drosophila melanogaster)
miR-25 Endonucleolytic Minimal RISC [cytosol]
(Mus musculus)
miR-25 Endonucleolytic Minimal RISC [cytosol]
(Rattus norvegicus)
miR-25 Endonucleolytic Minimal RISC [cytosol]
(Sus scrofa)
miR-25 Endonucleolytic Minimal RISC [cytosol]
(Xenopus tropicalis)
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