MicroRNA miR-22-3p, one of the two mature products of miR-22, binds the 3'UTR of PTEN mRNA (Poliseno et al. 2010). miR-22 causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-22 also functions as a part of the nonendonucleolytic RISC.
Poliseno, L, Salmena, L, Riccardi, L, Fornari, A, Song, MS, Hobbs, RM, Sportoletti, P, Varmeh, S, Egia, A, Fedele, G, Rameh, L, Loda, M, Pandolfi, PP
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