MicroRNA miR-22-3p, one of the two mature products of miR-22, binds the 3'UTR of PTEN mRNA (Poliseno et al. 2010). miR-22 causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-22 also functions as a part of the nonendonucleolytic RISC.
Rameh, L, Varmeh, S, Sportoletti, P, Fornari, A, Loda, M, Poliseno, L, Fedele, G, Song, MS, Riccardi, L, Hobbs, RM, Pandolfi, PP, Egia, A, Salmena, L
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