miR-17 microRNA binds PTEN mRNA

Stable Identifier
R-HSA-8944483
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-17 microRNA binds PTEN mRNA
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MicroRNA miR-17-5p, one of the two mature products of miR-17, binds the 3'UTR of PTEN mRNA (Xiao et al. 2008, Poliseno et al. 2010). miR-17 causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-17 also functions as a part of the nonendonucleolytic RISC.
Literature References
PubMed ID Title Journal Year
20388916 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

Rameh, L, Varmeh, S, Sportoletti, P, Fornari, A, Loda, M, Poliseno, L, Fedele, G, Song, MS, Riccardi, L, Hobbs, RM, Pandolfi, PP, Egia, A, Salmena, L

Sci Signal 2010
18327259 Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

Zhang, B, Xiao, C, Kutok, JL, Henderson, JM, Wang, J, Calado, DP, Srinivasan, L, Rajewsky, K, Patterson, HC

Nat. Immunol. 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
miR-17 RISC:VAPA mRNA [cytosol] (Homo sapiens)
Active Unit
miR-17 RISC [cytosol]
Regulator
miR-17 RISC:CNOT6L mRNA [cytosol] (Homo sapiens)
Active Unit
CNOT6L mRNA [cytosol]
Authored
Salmena, L  (2016-08-11)
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-03)
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