miR-17 microRNA binds PTEN mRNA

Stable Identifier
R-HSA-8944483
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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miR-17 microRNA binds PTEN mRNA
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MicroRNA miR-17-5p, one of the two mature products of miR-17, binds the 3'UTR of PTEN mRNA (Xiao et al. 2008, Poliseno et al. 2010). miR-17 causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-17 also functions as a part of the nonendonucleolytic RISC.

Literature References
PubMed ID Title Journal Year
18327259 Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

Xiao, C, Srinivasan, L, Calado, DP, Patterson, HC, Zhang, B, Wang, J, Henderson, JM, Kutok, JL, Rajewsky, K

Nat. Immunol. 2008
20388916 Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation

Poliseno, L, Salmena, L, Riccardi, L, Fornari, A, Song, MS, Hobbs, RM, Sportoletti, P, Varmeh, S, Egia, A, Fedele, G, Rameh, L, Loda, M, Pandolfi, PP

Sci Signal 2010
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This event is regulated
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Authored
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Salmena, L  (2016-08-11)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-03)