MicroRNA miR-17-5p, one of the two mature products of miR-17, binds the 3'UTR of PTEN mRNA (Xiao et al. 2008, Poliseno et al. 2010). miR-17 causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-17 also functions as a part of the nonendonucleolytic RISC.
Rameh, L, Varmeh, S, Sportoletti, P, Fornari, A, Loda, M, Poliseno, L, Fedele, G, Song, MS, Riccardi, L, Hobbs, RM, Pandolfi, PP, Egia, A, Salmena, L
Zhang, B, Xiao, C, Kutok, JL, Henderson, JM, Wang, J, Calado, DP, Srinivasan, L, Rajewsky, K, Patterson, HC
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