MAF1 translocates to the nucleus

Stable Identifier
R-HSA-8944457
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nuclear envelope
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MAF1 translocates to the nucleus
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Phosphorylation of MAF1 by the activated mTORC1 complex inhibits translocation of MAF1 to the nucleus, and hence its transcriptional activity, but the mechanism has not been elucidated (Shor et al. 2010).

Literature References
PubMed ID Title Journal Year
20233713 Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

Shor, B, Wu, J, Shakey, Q, Toral-Barza, L, Shi, C, Follettie, M, Yu, K

J. Biol. Chem. 2010
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This event is regulated
Negatively by
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Authored
Salmena, L  (2016-08-11)
Carracedo, A  (2016-08-11)
Orlic-Milacic, M  (2016-11-03)
Created
Orlic-Milacic, M  (2016-11-03)