MAF1 translocates to the nucleus

Stable Identifier
R-HSA-8944457
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nuclear envelope
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MAF1 translocates to the nucleus
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Phosphorylation of MAF1 by the activated mTORC1 complex inhibits translocation of MAF1 to the nucleus, and hence its transcriptional activity, but the mechanism has not been elucidated (Shor et al. 2010).

Literature References
PubMed ID Title Journal Year
20233713 Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

Yu, K, Follettie, M, Toral-Barza, L, Shakey, Q, Wu, J, Shor, B, Shi, C

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
Orthologous Events
MAF1 translocates to the nucleus (Caenorhabditis elegans)
MAF1 translocates to the nucleus (Canis familiaris)
MAF1 translocates to the nucleus (Danio rerio)
MAF1 translocates to the nucleus (Dictyostelium discoideum)
MAF1 translocates to the nucleus (Drosophila melanogaster)
MAF1 translocates to the nucleus (Gallus gallus)
MAF1 translocates to the nucleus (Mus musculus)
MAF1 translocates to the nucleus (Plasmodium falciparum)
MAF1 translocates to the nucleus (Rattus norvegicus)
MAF1 translocates to the nucleus (Saccharomyces cerevisiae)
MAF1 translocates to the nucleus (Schizosaccharomyces pombe)
Authored
Salmena, L  (2016-08-11)
Carracedo, A  (2016-08-11)
Orlic-Milacic, M  (2016-11-03)
Created
Orlic-Milacic, M  (2016-11-03)
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