The transcription factor JUN binds the AP-1 element in the PTEN gene promoter (Hettinger et al. 2007) and represses PTEN gene transcription. RAS/RAF/MAPK signaling positively affects JUN-mediated inhibition of PTEN transcription, but the mechanism is not known. The JUN partner FOS is not needed for JUN-mediated downregulation of PTEN (Vasudevan et al. 2007).
Hettinger, K, Zhang, JT, Vikhanskaya, F, de Belle, I, Lee, MK, Poh, MK, Sabapathy, K, Reddy, SA
Burikhanov, R, Vasudevan, KM, Goswami, A, Rangnekar, VM
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