JUN binds the PTEN gene promoter

Stable Identifier
R-HSA-8944047
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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JUN binds the PTEN gene promoter
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The transcription factor JUN binds the AP-1 element in the PTEN gene promoter (Hettinger et al. 2007) and represses PTEN gene transcription. RAS/RAF/MAPK signaling positively affects JUN-mediated inhibition of PTEN transcription, but the mechanism is not known. The JUN partner FOS is not needed for JUN-mediated downregulation of PTEN (Vasudevan et al. 2007).

Literature References
PubMed ID Title Journal Year
16676006 c-Jun promotes cellular survival by suppression of PTEN

Hettinger, K, Zhang, JT, Vikhanskaya, F, de Belle, I, Lee, MK, Poh, MK, Sabapathy, K, Reddy, SA

Cell Death Differ. 2007
17974977 Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras

Burikhanov, R, Vasudevan, KM, Goswami, A, Rangnekar, VM

Cancer Res. 2007
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
p-T,Y MAPK dimers [cytosol] (Homo sapiens)
Authored
Salmena, L  (2016-08-11)
Carracedo, A  (2016-08-11)
Orlic-Milacic, M  (2016-11-01)
Created
Orlic-Milacic, M  (2016-11-02)
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