The transcription factor JUN binds the AP-1 element in the PTEN gene promoter (Hettinger et al. 2007) and represses PTEN gene transcription. RAS/RAF/MAPK signaling positively affects JUN-mediated inhibition of PTEN transcription, but the mechanism is not known. The JUN partner FOS is not needed for JUN-mediated downregulation of PTEN (Vasudevan et al. 2007).
de Belle, I,