Reactome | JUN binds the PTEN gene promoter

JUN binds the PTEN gene promoter

Stable Identifier

R-HSA-8944047

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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The transcription factor JUN binds the AP-1 element in the PTEN gene promoter (Hettinger et al. 2007) and represses PTEN gene transcription. RAS/RAF/MAPK signaling positively affects JUN-mediated inhibition of PTEN transcription, but the mechanism is not known. The JUN partner FOS is not needed for JUN-mediated downregulation of PTEN (Vasudevan et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17974977	Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras Vasudevan, KM, Burikhanov, R, Goswami, A, Rangnekar, VM	Cancer Res.	2007
16676006	c-Jun promotes cellular survival by suppression of PTEN Hettinger, K, Vikhanskaya, F, Poh, MK, Lee, MK, de Belle, I, Zhang, JT, Reddy, SA, Sabapathy, K	Cell Death Differ.	2007