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GGT1(381-569) [plasma membrane]
Stable Identifier
R-HSA-8943263
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GGT1 light chain, GGT1lc, Gamma-glutamyltranspeptidase 1, GGT1_HUMAN, GGT1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
LTC4-CYSLTR mediated IL4 production (Homo sapiens)
GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)
GGT1, 5 dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(381-569) [plasma membrane] (Homo sapiens)
LTC4 binds CyslTR1,2 (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(381-569) [plasma membrane] (Homo sapiens)
Drug ADME (Homo sapiens)
Paracetamol ADME (Homo sapiens)
GGT dimers hydrolyse APAP-SG (Homo sapiens)
GGT dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(381-569) [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Aflatoxin activation and detoxification (Homo sapiens)
GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)
GGT dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(381-569) [plasma membrane] (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
GGT dimers hydrolyse GSH (Homo sapiens)
GGT dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(381-569) [plasma membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)
GGT1, 5 dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(381-569) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19440 GGT1
Gene Names
GGT1, GGT
Chain
chain:1-380, chain:381-569
Reference Genes
BioGPS Gene:2678 GGT1
COSMIC (genes):GGT1 GGT1
CTD Gene:2678 GGT1
dbSNP Gene:2678 GGT1
ENSEMBL:ENSG00000100031 GGT1
ENSEMBL_homo_sapiens_GENE:ENSG00000100031.19 GGT1
HGNC:4250 GGT1
KEGG Gene (Homo sapiens):2678 GGT1
Monarch:2678 GGT1
NCBI Gene:2678 GGT1
OMIM:612346 GGT1
UCSC:P19440 GGT1
Reference Transcript
RefSeq:NM_013430.2 GGT1
RefSeq:NM_013421.2 GGT1
RefSeq:NM_001288833.1 GGT1
Other Identifiers
11741396_s_at
16928293
17122238
17122240
17122242
17123034
17123036
17123038
207131_3p_x_at
207131_PM_x_at
207131_x_at
208284_3p_x_at
208284_PM_x_at
208284_x_at
209919_3p_x_at
209919_PM_x_at
209919_x_at
211417_3p_x_at
211417_PM_x_at
211417_x_at
215603_PM_x_at
215603_x_at
2493558
2493560
2493561
2493565
2493567
2678
32893_s_at
3901449
3901453
3901460
3937463
3937464
3937483
3939018
3939019
3939020
3939920
3939921
3939924
3939925
3939926
3939927
3939929
3939930
3939931
3939932
3939933
3939934
3939935
3939936
3939937
3939938
3939939
3939941
3939942
3939943
3939944
3939945
3939946
3939949
3939950
3939951
3940233
3940235
3940237
3952072
3952076
3952079
3952082
3952085
3952090
3952091
3952093
3952094
3952095
3953225
3953257
3953259
3953972
3953979
3953980
3953983
3953985
3953988
3953989
3953990
3953991
3953992
3954823
3955210
3955213
4038554
4038557
4038589
4038591
4038599
4038603
4038611
4038615
4038621
4038629
4038631
41868_at
715_s_at
76993_f_at
8071927
8074316
A_21_P0012281
A_23_P154986
GO:0000048
GO:0002376
GO:0002682
GO:0002951
GO:0003824
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006508
GO:0006520
GO:0006536
GO:0006575
GO:0006629
GO:0006631
GO:0006691
GO:0006749
GO:0006750
GO:0006751
GO:0006790
GO:0006954
GO:0007283
GO:0008233
GO:0016020
GO:0016740
GO:0016746
GO:0016787
GO:0019344
GO:0022414
GO:0031179
GO:0031638
GO:0036374
GO:0043226
GO:0050727
GO:0051604
GO:0070062
GO:0103068
GO:0140096
GO:1901750
HMNXSV003008629
HMNXSV003013451
HMNXSV003039302
Hs.314108.0.A1_3p_s_at
ILMN_1652604
ILMN_1686531
ILMN_1787180
ILMN_1813658
ILMN_2368585
PH_hs_0028212
PH_hs_0032802
PH_hs_0033869
PH_hs_0040704
TC22001026.hg
TC22001235.hg
g306748_3p_s_at
g306752_3p_s_at
g306752_3p_x_at
g306754_3p_s_at
g306754_3p_x_at
g9845490_3p_s_at
g9845492_3p_s_at
Participates
as a component of
GGT1 dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
GGT1(381-569) S452A [plasma membrane]
GGT1(381-569) D423E [plasma membrane]
GGT1(1-380) R107H [plasma membrane]
GGT1(381-569) S451A [plasma membrane]
GGT1(1-380) R107Q [plasma membrane]
GGT1(381-569) D423A [plasma membrane]
GGT1(1-380) [plasma membrane]
Inferred To
Dmel\CG4829 [plasma membrane]
(Drosophila melanogaster)
GGT2 [plasma membrane]
(Gallus gallus)
GGT1(381-569) [plasma membrane]
(Caenorhabditis elegans)
GGT1(381-569) [plasma membrane]
(Mus musculus)
GGT1(381-569) [plasma membrane]
(Rattus norvegicus)
GGT1(381-569) [plasma membrane]
(Saccharomyces cerevisiae)
GGT1(381-569) [plasma membrane]
(Schizosaccharomyces pombe)
GGT1 [plasma membrane]
(Bos taurus)
GGT1 [plasma membrane]
(Canis familiaris)
GGT1 [plasma membrane]
(Sus scrofa)
Homologues of GGT1(381-569) [plasma membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_038265.2
,
NP_038347.2
,
NP_001275762.1
OpenTargets
ENSG00000100031
GeneCards
P19440
HPA
ENSG00000100031-GGT1
ZINC target
P19440
Ensembl
ENSG00000100031
,
ENST00000404532
,
ENSP00000384820
,
ENST00000401885
,
ENST00000425895
,
ENST00000403838
,
ENSP00000383231
,
ENSP00000387499
,
ENSP00000385445
,
ENSP00000383232
,
ENST00000400382
,
ENSP00000384381
,
ENST00000400380
PRO
P19440
Pharos - Targets
P19440
Orphanet
26453
HMDB Protein
HMDBP00730
PDB
4ZCG
,
4ZC6
,
5V4Q
,
4ZBK
,
4GDX
,
4Z9O
,
4GG2
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