Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TMEM129 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-8943134
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
E3 ubiquitin-protein ligase TM129 ecNumber6.3.2.-/ecNumber, TM129_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 (Homo sapiens)
TMEM129 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129 [endoplasmic reticulum membrane] (Homo sapiens)
US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129 [endoplasmic reticulum membrane] (Homo sapiens)
US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP (Homo sapiens)
TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129 [endoplasmic reticulum membrane] (Homo sapiens)
US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:A0AVI4 TMEM129
Gene Names
TMEM129
Chain
chain:1-362
Reference Genes
BioGPS Gene:92305 A0AVI42
COSMIC (genes):TMEM129 TMEM129
CTD Gene:92305 A0AVI42
dbSNP Gene:92305 TMEM129
ENSEMBL:ENSG00000168936 TMEM129
HGNC:25137 A0AVI42
KEGG:hsa:92305 A0AVI42
Monarch:92305 A0AVI42
NCBI Gene:92305 A0AVI42
OMIM:615975 A0AVI42
UCSC:A0AVI4 A0AVI42
Reference Transcript
RefSeq:NM_138385.4 A0AVI42
RefSeq:NM_001127266.2 A0AVI42
Participates
as a component of
TMEM129:DERL1:VIMP:VCP:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] (Homo sapiens)
Cross References
RefSeq
NP_001120738.1
,
NP_612394.1
ENSEMBL
ENSP00000372394
,
ENST00000303277
,
ENST00000382936
,
ENSG00000168936
,
ENSP00000305243
OpenTargets
ENSG00000168936
IntEnz
2.3.2.27
GeneCards
TMEM129
HPA
ENSG00000168936-TMEM129
PRO
A0AVI4
Pharos - Targets
A0AVI4
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text