Reactome | HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

Stable Identifier

R-HSA-8943041

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

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At stalled replication forks, the E3 ubiquitin ligase HLTF interacts with PCNA monoubiquitinated at lysine-164 (monoUb-K164-PCNA), the RAD18:UBE2B complex (RAD18:RAD6 complex), and the Ub:UBE2N:UBE2V2 complex (UBC13:MMS2 complex with ubiquitin conjugated to UBC13) (Unk et al. 2008, Motegi et al. 2008, MacKay et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19723507	Biochemical characterisation of the SWI/SNF family member HLTF MacKay, C, Toth, R, Rouse, J	Biochem. Biophys. Res. Commun.	2009
18719106	Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Motegi, A, Liaw, HJ, Lee, KY, Roest, HP, Maas, A, Wu, X, Moinova, H, Markowitz, SD, Ding, H, Hoeijmakers, JH, Myung, K	Proc. Natl. Acad. Sci. U.S.A.	2008
18316726	Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination Unk, I, Hajdu, I, Fatyol, K, Hurwitz, J, Yoon, JH, Prakash, L, Prakash, S, Haracska, L	Proc. Natl. Acad. Sci. U.S.A.	2008