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p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm]
Stable Identifier
R-HSA-8942837
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Homo sapiens)
Participants
components
Cyclin D [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Homo sapiens)
Participant Of
hasComponent
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm]
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm]
hasMember
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
Inferred To
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Bos taurus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Caenorhabditis elegans)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Danio rerio)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Drosophila melanogaster)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Mus musculus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Xenopus tropicalis)
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