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VRK3 [nucleoplasm]
Stable Identifier
R-HSA-8942507
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Inactive serine/threonine-protein kinase VRK3, VRK3_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
VRK3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IV63 VRK3
Gene Names
VRK3
Chain
chain:1-474
Reference Genes
BioGPS Gene:51231 VRK3
COSMIC (genes):VRK3 VRK3
CTD Gene:51231 VRK3
dbSNP Gene:51231 VRK3
ENSEMBL:ENSG00000105053 VRK3
ENSEMBL_homo_sapiens_GENE:ENSG00000105053.11 VRK3
HGNC:18996 VRK3
KEGG Gene (Homo sapiens):51231 VRK3
Monarch:51231 VRK3
NCBI Gene:51231 VRK3
OMIM:619771 VRK3
UCSC:Q8IV63 VRK3
Reference Transcript
RefSeq:XM_005258972.3 VRK3
RefSeq:XM_005258971.3 VRK3
RefSeq:NM_001025778.1 VRK3
RefSeq:XM_006723238.3 VRK3
RefSeq:XM_011527023.2 VRK3
RefSeq:NM_016440.3 VRK3
RefSeq:NM_001308420.1 VRK3
RefSeq:XM_006723237.3 VRK3
Other Identifiers
11744164_a_at
11746657_a_at
11761437_a_at
11762624_a_at
16874467
218022_PM_at
218022_at
221998_PM_s_at
221998_s_at
221999_PM_at
221999_at
3868284
3868286
3868287
3868288
3868289
3868290
3868298
3868299
3868301
3868302
3868303
3868306
3868309
3868311
3868312
3868313
3868315
3868316
3868318
3868319
46718_at
51231
57727_at
8038515
A_23_P107933
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0006468
GO:0007165
GO:0007519
GO:0016740
GO:0019903
GO:0023052
GO:0036211
GO:0043226
GO:0043231
GO:0048856
GO:0070373
GO:0140096
HMNXSV003041597
HMNXSV003046333
Hs.98289.1.S1_3p_at
ILMN_1771697
ILMN_1805535
ILMN_2348403
PH_hs_0025893
TC19001730.hg
g7705992_3p_at
Participates
as a component of
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
Inferred To
Homologues of VRK3 [nucleoplasm]
(Drosophila melanogaster)
VRK3 [nucleoplasm]
(Bos taurus)
VRK3 [nucleoplasm]
(Drosophila melanogaster)
VRK3 [nucleoplasm]
(Gallus gallus)
VRK3 [nucleoplasm]
(Sus scrofa)
zgc:113420 [nucleoplasm]
(Danio rerio)
Vrk3 [nucleoplasm]
(Mus musculus)
Vrk3 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
XP_006723301.1
,
XP_005259028.1
,
XP_011525325.1
,
XP_005259029.1
,
XP_006723300.1
,
NP_057524.3
,
NP_001020949.1
,
NP_001295349.1
Guide to Pharmacology - Targets
2277
OpenTargets
ENSG00000105053
GeneCards
Q8IV63
HPA
ENSG00000105053-VRK3
ZINC target
Q8IV63
Ensembl
ENST00000594092
,
ENSP00000472541
,
ENSP00000470156
,
ENST00000377011
,
ENSP00000366210
,
ENSG00000105053
,
ENSP00000473171
,
ENST00000599538
,
ENST00000316763
,
ENSP00000469880
,
ENSP00000324636
,
ENST00000594948
,
ENST00000601341
PRO
Q8IV63
Pharos - Targets
Q8IV63
PDB
2JII
HMDB Protein
HMDBP09479
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