Reactome | GPHA2 [extracellular region]

GPHA2 [extracellular region]

Stable Identifier

R-HSA-8942422

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Glycoprotein hormone alpha-2, GPHA2_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Hormone ligand-binding receptors (Homo sapiens)
        
        Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin (Homo sapiens)
        
        TSHR:Thyrotropin [plasma membrane] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)
        
        Thyrotropin, Thyrostimulin [extracellular region] (Homo sapiens)
        
        Thyrostimulin [extracellular region] (Homo sapiens)
        
        GPHA2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96T91 GPHA2

Gene Names

GPHA2, GPA2, ZSIG51

Chain

signal peptide:1-23, chain:24-129

Reference Genes

BioGPS Gene:170589 GPHA2

COSMIC (genes):GPHA2 GPHA2

CTD Gene:170589 GPHA2

dbSNP Gene:170589 GPHA2

ENSEMBL:ENSG00000149735 GPHA2

HGNC:18054 GPHA2

KEGG:hsa:170589 GPHA2

Monarch:170589 GPHA2

NCBI Gene:170589 GPHA2

OMIM:609651 GPHA2

UCSC:Q96T91 GPHA2

Reference Transcript

Other Identifiers

11730027_at

16740211

170589

237230_PM_at

237230_at

3377323

3377324

3377325

3377326

3377327

3377328

3377329

7949320

90535_at

A_23_P47181

GE570605

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0007166

GO:0007189

GO:0031531

GO:0046982

GO:0048018

GO:0098772

HMNXSV003018541

Hs.127223.0.A1_3p_at

ILMN_1766204

PH_hs_0025476

TC11001919.hg

Participates

as a component of

Thyrostimulin [extracellular region] (Homo sapiens)

Inferred To

flr-2 [extracellular region] (Caenorhabditis elegans)

Gpha2 [extracellular region] (Mus musculus)

Gpha2 [extracellular region] (Rattus norvegicus)

gpha2 [extracellular region] (Danio rerio)

Gpa2 [extracellular region] (Drosophila melanogaster)

GPHA2 [extracellular region] (Bos taurus)

GPHA2 [extracellular region] (Canis familiaris)

GPHA2 [extracellular region] (Sus scrofa)

Cross References

RefSeq

XP_011543077.1, NP_570125.1, XP_011543078.1

ENSEMBL

ENSP00000432918, ENSG00000149735, ENST00000279168, ENSP00000279168, ENST00000533257

OpenTargets

ENSG00000149735

GeneCards

GPHA2

HPA

ENSG00000149735-GPHA2

PRO

Q96T91

Pharos - Targets

Q96T91

GlyGen

Q96T91

HMDB Protein

HMDBP08129

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q0VG06 FAAP100	2	FAAP100 [nucleoplasm] (R-HSA-419545) FAAP100 [cytosol] (R-HSA-420799)	0.527	2
UniProt:Q92824 PCSK5	2	PCSK5(115-913) [Golgi lumen] (R-HSA-166558) PCSK5 [extracellular region] (R-HSA-6784682)	0.527	2
UniProt:Q8WXG9 ADGRV1	1	GPR98 [plasma membrane] (R-HSA-9618718)	0.527	2