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Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate
Stable Identifier
R-HSA-8942075
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
Peroxynitrite and carbon dioxide react to nitrosoperoxycarbonate (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxynitrite anion rapidly reacts with carbon dioxide to yield a reactive adduct, nitrosoperoxycarbonate anion (ONOOCOO-), which can participate in oxidation and nitration processes, thus redirecting the primary reactivity of peroxynitrite (Denicola A et al. 1996).
Literature References
PubMed ID
Title
Journal
Year
8806753
Peroxynitrite reaction with carbon dioxide/bicarbonate: kinetics and influence on peroxynitrite-mediated oxidations
Radi, R
,
Freeman, BA
,
Denicola, A
,
Trujillo, M
Arch. Biochem. Biophys.
1996
Participants
Input
CO2 [cytosol]
Peroxynitrite [cytosol]
Output
nitrosoperoxycarbonate [cytosol]
Participates
as an event of
ROS and RNS production in phagocytes (Homo sapiens)
Authored
Shamovsky, V (2018-10-23)
Reviewed
Nüsse, O (2018-11-07)
Created
Shamovsky, V (2016-10-08)
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