Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange

Stable Identifier
R-HSA-8941628
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange
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RAS nucleotide is stimulated downstream of activated FGFR3 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).

Literature References
PubMed ID Title Journal Year
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
17227708 The role of Shp2 (PTPN11) in cancer

Mohi, MG, Neel, BG

Curr. Opin. Genet. Dev. 2007
18452557 Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

Gotoh, N

Cancer Sci 2008
Participants
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Output
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This event is regulated
Requirements
Orthologous Events
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Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2016-10-05)