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LRRC8A [plasma membrane]
Stable Identifier
R-HSA-8941524
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Volume-regulated anion channel subunit LRRC8A, LRC8A_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Miscellaneous transport and binding events (Homo sapiens)
VRAC heteromer transports I-, Cl- from cytosol to extracellular region (Homo sapiens)
VRAC heteromer [plasma membrane] (Homo sapiens)
LRRC8A:LRRC8B [plasma membrane] (Homo sapiens)
LRRC8A [plasma membrane] (Homo sapiens)
LRRC8A:LRRC8C [plasma membrane] (Homo sapiens)
LRRC8A [plasma membrane] (Homo sapiens)
LRRC8A:LRRC8D [plasma membrane] (Homo sapiens)
LRRC8A [plasma membrane] (Homo sapiens)
LRRC8A:LRRC8E [plasma membrane] (Homo sapiens)
LRRC8A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWT6 LRRC8A
Gene Names
LRRC8A, KIAA1437, LRRC8, SWELL1, UNQ221/PRO247
Chain
chain:1-810
Reference Genes
BioGPS Gene:56262 LRRC8A
COSMIC (genes):LRRC8A LRRC8A
CTD Gene:56262 LRRC8A
dbSNP Gene:56262 LRRC8A
ENSEMBL:ENSG00000136802 LRRC8A
HGNC:19027 LRRC8A
KEGG:hsa:56262 LRRC8A
Monarch:56262 LRRC8A
NCBI Gene:56262 LRRC8A
OMIM:608360 LRRC8A
UCSC:Q8IWT6 LRRC8A
Reference Transcript
RefSeq:XM_005252096.3 LRRC8A
RefSeq:XM_011518864.2 LRRC8A
RefSeq:NM_019594.3 LRRC8A
RefSeq:XM_011518863.1 LRRC8A
RefSeq:NM_001127245.1 LRRC8A
RefSeq:NM_001127244.1 LRRC8A
RefSeq:XM_011518865.2 LRRC8A
RefSeq:XM_005252095.2 LRRC8A
RefSeq:XM_006717186.2 LRRC8A
Other Identifiers
11729413_a_at
11729414_s_at
11757458_s_at
17089868
224624_3p_at
224624_PM_at
224624_at
233487_PM_s_at
233487_s_at
3190779
3190780
3190781
3190784
3190785
3190786
3190788
3190789
3190790
3190791
3190792
3190793
3190794
3190795
54817_at
56262
65577_at
8158424
A_23_P250274
A_24_P376287
GE53971
GE903681
GO:0001678
GO:0002329
GO:0002376
GO:0005215
GO:0005225
GO:0005253
GO:0005515
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005886
GO:0006820
GO:0006884
GO:0006970
GO:0007283
GO:0009986
GO:0015734
GO:0015810
GO:0016020
GO:0022414
GO:0030154
GO:0032024
GO:0034214
GO:0034220
GO:0034702
GO:0042802
GO:0043226
GO:0045663
GO:0055085
GO:0065003
GO:0098656
GO:0140360
GO:0140361
GO:1902476
HMNXSV003002253
Hs.173484.0.S2_3p_at
Hs.173484.0.S2_3p_s_at
Hs.173484.1.S1_3p_a_at
ILMN_1739840
PH_hs_0010397
TC09000704.hg
Participates
as a component of
LRRC8A:LRRC8C [plasma membrane] (Homo sapiens)
LRRC8A:LRRC8D [plasma membrane] (Homo sapiens)
LRRC8A:LRRC8E [plasma membrane] (Homo sapiens)
LRRC8A:LRRC8B [plasma membrane] (Homo sapiens)
Inferred To
soc-2 [plasma membrane]
(Caenorhabditis elegans)
Lrrc8a [plasma membrane]
(Mus musculus)
Lrrc8a [plasma membrane]
(Rattus norvegicus)
Sur-8 [plasma membrane]
(Drosophila melanogaster)
LRRC8A [plasma membrane]
(Bos taurus)
LRRC8A [plasma membrane]
(Canis familiaris)
LRRC8A [plasma membrane]
(Gallus gallus)
LRRC8A [plasma membrane]
(Sus scrofa)
lrrc8aa [plasma membrane]
(Danio rerio)
Cross References
ENSEMBL
ENST00000372600
,
ENST00000372599
,
ENST00000259324
,
ENSP00000259324
,
ENSP00000361682
,
ENSP00000361680
OpenTargets
ENSG00000136802
HPA
ENSG00000136802-LRRC8A
PRO
Q8IWT6
Pharos - Targets
Q8IWT6
Orphanet
LRRC8A
PDB
8DXR
,
8DXP
,
8DXN
,
8DXO
,
7XZH
,
5ZSU
,
8DXQ
,
6DJB
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