SH3PXD2A binds ADAM12,ADAM15,ADAM19

Stable Identifier
R-HSA-8941234
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SH3PXD2A (TKS5, FISH) was discovered as an adaptor protein and Src substrate (Lock et al. 1998). It is essential for invadopodia and podosome formation in many different cell types. It is not required for precursor initiation but is needed for precursor stabilization (Sharma et al. 2013). It contains a phox homology (PX) domain that binds the membrane phosphoinositides PI3P and PI(3,4)P2 (Abram et al. 2003) In Src-transformed NIH 3T3 cells, TKS5 and PI(3,4)P2 localize to podosomes via a GRB2-dependent mechanism (Oikawa et al. 2008).

TKS5 directly binds to the ADAM family proteases 12, 15, and 19 (Abram et al. 2003), N-WASP, dynamin-2, and Grb2 (Oikawa et al. 2008) and NCK1 and 2 (Styli et al. 2009). In vivo, decreased Tks5 expression correlates with reductions in tumor growth, metastasis, and angiogenesis (Blouw et al. 2008).

Literature References
PubMed ID Title Journal Year
12615925 The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells

Abram, CL, Seals, DF, Pass, I, Salinsky, D, Maurer, L, Roth, TM, Courtneidge, SA

J. Biol. Chem. 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!