IL36RN, IL1F10 bind IL1RL2

Stable Identifier
R-HSA-8940998
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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IL36RN, IL1F10 bind IL1RL2
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Interleukin-36 receptor antagonist protein (IL36RN, IL-36Ra) binds the interleukin-36 receptor subunit IL1RL2 (Interleukin-1 receptor-like 2, IL-1Rrp2). This inhibits the activity of interleukin-36 (IL36) by preventing IL1RL2 and IL1RAP from associating to form the interleukin-36 receptor complex (Towne et al. 2015). Similarly, Interleukin-1 family member 10 (IL1F10), also referred to as Interleukin-38, binds the interleukin-36 receptor subunit IL1RL2 inhibiting IL36 signaling (van de Veerdonk et al. 2012). Homozygous and compound heterozygous mutations in IL36RN have been identified to cause generalized pustular psoriasis (GPP) (Onoufriadis et al. 2011, Marrakchi et al. 2011).
Literature References
PubMed ID Title Journal Year
21965679 Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity

Towne, JE, Sims, JE, Gabel, CA, Douangpanya, J, Shen, M, Lipsky, BP, Renshaw, BR

J. Biol. Chem. 2011
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Orthologous Events
IL36RN, IL1F10 bind IL1RL2 (Bos taurus)
IL36RN, IL1F10 bind IL1RL2 (Canis familiaris)
IL36RN, IL1F10 bind IL1RL2 (Mus musculus)
IL36RN, IL1F10 bind IL1RL2 (Rattus norvegicus)
IL36RN, IL1F10 bind IL1RL2 (Xenopus tropicalis)
Authored
Jupe, S  (2016-09-29)
Reviewed
Ainscough, JS  (2017-01-20)
Wittmann, M  (2017-01-20)
Gabay, C  (2017-01-12)
Created
Jupe, S  (2016-09-29)
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