Reactome | Neurolysin degrades neurotensin

Neurolysin degrades neurotensin

Stable Identifier

R-HSA-8940959

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Neurolysin (NLN, EC 3.4.24.16) is a member of the thermolysin-like mammalian zinc endopeptidase family (Dauch et al. 1995). It is maximally active at neutral pH and responsible for hydrolytic processing of bioactive peptides in the extracellular environment (Shrimpton et al. 2002). It cleaves 3 residues from the C-teminal end of Neurotensin (Dauch et al. 1995). Other endogenous substrates of NLN include bradykinin, angiotensins I and II, substance P, hemopressin, dynorphin A(1–8), metorphamide, and somatostatin (Wangler et al. 2016). The functional significance of NLN is poorly understood (Checler 2014). In vivo studies have linked it to neurotensin-dependent nociception (Vincent et al. 1997), bradykinin-mediated hypotension, microvascular permeability and hyperalgesia (Gomez et al. 2011), and pathogenesis of stroke (Rashid et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
27496565	Preparation and preliminary characterization of recombinant neurolysin for in vivo studies Wangler, NJ, Jayaraman, S, Zhu, R, Mechref, Y, Abbruscato, TJ, Bickel, U, Karamyan, VT	J. Biotechnol.	2016
3525564	Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes Checler, F, Vincent, JP, Kitabgi, P	J. Biol. Chem.	1986