MMP13 gene expression is stimulated by RUNX2:CBFB

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R-HSA-8940007
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Reaction [omitted]
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Homo sapiens
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RUNX2:CBFB-mediated transcription of the MMP13 gene, encoding Colagenase-3 (Matrix metalloproteinase-13), is stimulated by AKT-mediated phosphorylation of RUNX2 and is implicated in invasiveness of breast cancer cells (Pande et al. 2013).

Literature References
PubMed ID Title Journal Year
23389849 Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

Pande, S, Browne, G, Padmanabhan, S, Zaidi, SK, Lian, JB, van Wijnen, AJ, Stein, JL, Stein, GS

J. Cell. Physiol. 2013
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