MMP13 gene expression is stimulated by RUNX2:CBFB

Stable Identifier
R-HSA-8940007
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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MMP13 gene expression is stimulated by RUNX2:CBFB
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RUNX2:CBFB-mediated transcription of the MMP13 gene, encoding Colagenase-3 (Matrix metalloproteinase-13), is stimulated by AKT-mediated phosphorylation of RUNX2 and is implicated in invasiveness of breast cancer cells (Pande et al. 2013).
Literature References
PubMed ID Title Journal Year
23389849 Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

van Wijnen, AJ, Browne, G, Lian, JB, Padmanabhan, S, Stein, JL, Stein, GS, Pande, S, Zaidi, SK

J. Cell. Physiol. 2013
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S196,T198,T200-RUNX2:CBFB:MMP13 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S196,T198,T200-RUNX2:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-22)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-22)
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