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ESR1:estrogen:RUNX2 gene [nucleoplasm]
Stable Identifier
R-HSA-8939910
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
Activated ESR1 binds the RUNX2 gene promoter (Homo sapiens)
ESR1:estrogen:RUNX2 gene [nucleoplasm] (Homo sapiens)
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1 (Homo sapiens)
ESR1:estrogen:RUNX2 gene [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23403054
Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform
Kammerer, M
,
Gutzwiller, S
,
Stauffer, D
,
Delhon, I
,
Seltenmeyer, Y
,
Fournier, B
Mol. Cell. Endocrinol.
2013
Participants
components
ESR1:ESTG [nucleoplasm] (Homo sapiens)
RUNX2 gene [nucleoplasm] (Homo sapiens)
Participant Of
output
Activated ESR1 binds the RUNX2 gene promoter
This entity regulates
Positively
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1
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